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Titel: Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy
VerfasserIn: Hofbauer, Joshua
Hauck, Andreas
Matos, Carina
Babl, Nathalie
Decking, Sonja-Maria
Rechenmacher, Michael
Schulz, Christian
Regotta, Sabine
Mickler, Marion
Haferkamp, Sebastian
Siska, Peter J.
Herr, Wolfgang
Renner, Kathrin
Kreutz, Marina
Schnell, Annette
Sprache: Englisch
Titel: Biomolecules
Bandnummer: 12
Heft: 5
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: PD-1
immunotherapy
PD-1+ monocytes
metabolism
hormones
immune cells
cholesterol
testosterone
free androgen index
hemoglobin
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Although the discovery of immune checkpoints was hailed as a major breakthrough in can cer therapy, generating a sufficient response to immunotherapy is still limited. Thus, the objective of this exploratory, hypothesis-generating study was to identify potentially novel peripheral biomarkers and discuss the possible predictive relevance of combining scarcely investigated metabolic and hor monal markers with immune subsets. Sixteen markers that differed significantly between responders and non-responders were identified. In a further step, the correlation with progression-free survival (PFS) and false discovery correction (Benjamini and Hochberg) revealed potential predictive roles for the immune subset absolute lymphocyte count (rs = 0.51; p = 0.0224 *), absolute basophil count (rs = 0.43; p = 0.04 *), PD-1+ monocytes (rs = −0.49; p = 0.04 *), hemoglobin (rs = 0.44; p = 0.04 *), metabolic markers LDL (rs = 0.53; p = 0.0224 *), free androgen index (rs = 0.57; p = 0.0224 *) and CRP (rs = −0.46; p = 0.0352 *). The absolute lymphocyte count, LDL and free androgen index were the most significant individual markers, and combining the immune subsets with the metabolic markers into a biomarker ratio enhanced correlation with PFS (rs = −0.74; p ≤ 0.0001 ****). In summary, in addition to well-established markers, we identified PD-1+ monocytes and the free androgen index as potentially novel peripheral markers in the context of immunotherapy. Furthermore, the combination of immune subsets with metabolic and hormonal markers may have the potential to enhance the power of future predictive scores and should, therefore, be investigated further in larger trials.
DOI der Erstveröffentlichung: 10.3390/biom12050716
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-362747
hdl:20.500.11880/32955
http://dx.doi.org/10.22028/D291-36274
ISSN: 2218-273X
Datum des Eintrags: 30-Mai-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/biom12050716/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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