Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
doi:10.22028/D291-36274
Titel: | Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy |
VerfasserIn: | Hofbauer, Joshua Hauck, Andreas Matos, Carina Babl, Nathalie Decking, Sonja-Maria Rechenmacher, Michael Schulz, Christian Regotta, Sabine Mickler, Marion Haferkamp, Sebastian Siska, Peter J. Herr, Wolfgang Renner, Kathrin Kreutz, Marina Schnell, Annette |
Sprache: | Englisch |
Titel: | Biomolecules |
Bandnummer: | 12 |
Heft: | 5 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | PD-1 immunotherapy PD-1+ monocytes metabolism hormones immune cells cholesterol testosterone free androgen index hemoglobin |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Although the discovery of immune checkpoints was hailed as a major breakthrough in can cer therapy, generating a sufficient response to immunotherapy is still limited. Thus, the objective of this exploratory, hypothesis-generating study was to identify potentially novel peripheral biomarkers and discuss the possible predictive relevance of combining scarcely investigated metabolic and hor monal markers with immune subsets. Sixteen markers that differed significantly between responders and non-responders were identified. In a further step, the correlation with progression-free survival (PFS) and false discovery correction (Benjamini and Hochberg) revealed potential predictive roles for the immune subset absolute lymphocyte count (rs = 0.51; p = 0.0224 *), absolute basophil count (rs = 0.43; p = 0.04 *), PD-1+ monocytes (rs = −0.49; p = 0.04 *), hemoglobin (rs = 0.44; p = 0.04 *), metabolic markers LDL (rs = 0.53; p = 0.0224 *), free androgen index (rs = 0.57; p = 0.0224 *) and CRP (rs = −0.46; p = 0.0352 *). The absolute lymphocyte count, LDL and free androgen index were the most significant individual markers, and combining the immune subsets with the metabolic markers into a biomarker ratio enhanced correlation with PFS (rs = −0.74; p ≤ 0.0001 ****). In summary, in addition to well-established markers, we identified PD-1+ monocytes and the free androgen index as potentially novel peripheral markers in the context of immunotherapy. Furthermore, the combination of immune subsets with metabolic and hormonal markers may have the potential to enhance the power of future predictive scores and should, therefore, be investigated further in larger trials. |
DOI der Erstveröffentlichung: | 10.3390/biom12050716 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-362747 hdl:20.500.11880/32955 http://dx.doi.org/10.22028/D291-36274 |
ISSN: | 2218-273X |
Datum des Eintrags: | 30-Mai-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Materials |
In Beziehung stehendes Objekt: | https://www.mdpi.com/article/10.3390/biom12050716/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
biomolecules-12-00716.pdf | 2,46 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons