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Titel: COVID-19 Vaccination of Individuals with Down Syndrome—Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated
VerfasserIn: Hüls, Anke
Feany, Patrick T.
Zisman, Sophia Isabella
Costa, Alberto C. S.
Dierssen, Mara
Balogh, Robert
Bargagna, Stefania
Baumer, Nicole T.
Brandão, Ana Claudia
Carfi, Angelo
Chicoine, Brian Allen
Ghosh, Sujay
Lakhanpaul, Monica
Levin, Johannes
Lunsky, Yona
Manso, Coral
Okun, Eitan
Real de Asua, Diego
Rebillat, Anne-Sophie
Rohrer, Tilman R.
Sgandurra, Giuseppina
Valentini, Diletta
Sherman, Stephanie L.
Strydom, Andre
on behalf of the Trisomy 21 Research Society COVID-19 Initiative
Sprache: Englisch
Titel: Vaccines
Bandnummer: 10
Heft: 4
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: Trisomy 21
down syndrome
COVID-19
SARS-CoV-2
BNT162b2
mRNA-1273
ChAdOx1 nCoV-19
Ad26.COV2.S
vaccine hesitancy
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Individuals with Down syndrome (DS) are among the groups with the highest risk for severe COVID-19. Better understanding of the efficacy and risks of COVID-19 vaccines for individuals with DS may help improve uptake of vaccination. The T21RS COVID-19 Initiative launched an international survey to obtain information on safety and efficacy of COVID-19 vaccines for individuals with DS. De-identified survey data collected between March and December 2021 were analyzed. Of 2172 individuals with DS, 1973 (91%) had received at least one vaccine dose (57% BNT162b2), 107 (5%) were unvaccinated by choice, and 92 (4%) were unvaccinated for other reasons. Most participants had either no side effects (54%) or mild ones such as pain at the injection site (29%), fatigue (12%), and fever (7%). Severe side effects occurred in <0.5% of participants. About 1% of the vaccinated individuals with DS contracted COVID-19 after vaccination, and all recovered. Individuals with DS who were unvaccinated by choice were more likely to be younger, previously recovered from COVID-19, and also unvaccinated against other recommended vaccines. COVID-19 vaccines have been shown to be safe for individuals with DS and effective in terms of resulting in minimal breakthrough infections and milder disease outcomes among fully vaccinated individuals with DS.
DOI der Erstveröffentlichung: 10.3390/vaccines10040530
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-360372
hdl:20.500.11880/32948
http://dx.doi.org/10.22028/D291-36037
ISSN: 2076-393X
Datum des Eintrags: 30-Mai-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://www.mdpi.com/2076-393X/10/4/530/s1?version=1648546734
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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