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doi:10.22028/D291-36029
Titel: | Is vimentin a potential prognostic factor for patients with triple-negative breast cancer? |
VerfasserIn: | Schmidt, Gilda Solomayer, Erich-Franz Bohle, Rainer Maria Gerlinger, Christoph Radosa, Julia Caroline Endrikat, Jan Kasoha, Mariz |
Sprache: | Englisch |
Titel: | Journal of Cancer Research and Clinical Oncology |
Bandnummer: | 146 |
Heft: | 8 |
Seiten: | 2109–2116 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2020 |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Objective To evaluate the prognostic potential of vimentin, p53, EGFR, CK5/6, CK 14, and CK 17 in patients with triple-negative breast cancer (TNBC). Material and methods Tumor specimens of 60 patients with histologically confirmed TNBC were retrospectively analyzed. Formalin-fixed paraffin-embedded blocks of the tumor tissue were used to prepare tissue microarrays (TMAs). After immune-histochemical staining, protein expression of vimentin, p53, EGFR, CK5/6, CK 14, and CK 17 was determined and the immunoreactive score (IRS) was calculated. The protein expression was correlated to overall (OS) and disease-free survival (DFS). Results Ninety percent of patients suffered from an invasive ductal carcinoma T1 or T2, 66.7% were N0, and 70% had a G3 tumor with Ki67 of > 14%. Vimentin expression was found in 28/60 patients (46.7%), p53 expression in 30/60 patients (50%), and EGFR expression in 3/60 patients (5%). CK5/6, CK14, and CK17 expression was found in 60.0%, 63.3%, and 66.7%, respectively. Vimentin expression vs no expression was associated with significantly higher mean Ki67 values (52.5% vs. 31.1%; p = 0.0013) and significantly higher p53 expression (67.9% vs. 34.4%; p = 0.0097). No significant association between vimentin expression and OS (p = 0.7710) or DFS (p = 0.5558) was found during a mean follow-up of 92 months. Conclusion None of the six proteins proved to be suitable prognostic factors for OS and DSF in patients with TNBC. |
DOI der Erstveröffentlichung: | 10.1007/s00432-020-03210-0 |
URL der Erstveröffentlichung: | https://link.springer.com/article/10.1007/s00432-020-03210-0 |
Link zu diesem Datensatz: | hdl:20.500.11880/32826 http://dx.doi.org/10.22028/D291-36029 |
ISSN: | 1432-1335 0171-5216 |
Datum des Eintrags: | 21-Apr-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Frauenheilkunde M - Pathologie |
Professur: | M - Prof. Dr. Rainer M. Bohle M - Prof. Dr. E.-F. Solomayer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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