Please use this identifier to cite or link to this item: doi:10.22028/D291-35972
Title: The Controversial Role of HCY and Vitamin B Deficiency in Cardiovascular Diseases
Author(s): Herrmann, Wolfgang
Herrmann, Markus
Language: English
Title: Nutrients
Volume: 14
Issue: 7
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: homocysteine
B vitamins
B-vitamin supplementation
telomere shortening
vascular dysfunction
cardiovascular disease
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Plasma homocysteine (HCY) is an established risk factor for cardiovascular disease CVD and stroke. However, more than two decades of intensive research activities has failed to demonstrate that Hcy lowering through B-vitamin supplementation results in a reduction in CVD risk. Therefore, doubts about a causal involvement of hyperhomocysteinemia (HHcy) and B-vitamin deficiencies in atherosclerosis persist. Existing evidence indicates that HHcy increases oxidative stress, causes endoplasmatic reticulum (ER) stress, alters DNA methylation and, thus, modulates the expression of numerous pathogenic and protective genes. Moreover, Hcy can bind directly to proteins, which can change protein function and impact the intracellular redox state. As most mechanistic evidence is derived from experimental studies with rather artificial settings, the relevance of these results in humans remains a matter of debate. Recently, it has also been proposed that HHcy and B-vitamin deficiencies may promote CVD through accelerated telomere shortening and telomere dysfunction. This review provides a critical overview of the existing literature regarding the role of HHcy and B-vitamin deficiencies in CVD. At present, the CVD risk associated with HHcy and B vitamins is not effectively actionable. Therefore, routine screening for HHcy in CVD patients is of limited value. However, B-vitamin depletion is rather common among the elderly, and in such cases existing deficiencies should be corrected. While Hcy-lowering with high doses of B vitamins has no beneficial effects in secondary CVD prevention, the role of Hcy in primary disease prevention is insufficiently studied. Therefore, more intervention and experimental studies are needed to address existing gaps in knowledge.
DOI of the first publication: 10.3390/nu14071412
Link to this record: urn:nbn:de:bsz:291--ds-359726
ISSN: 2072-6643
Date of registration: 12-Apr-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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