Please use this identifier to cite or link to this item: doi:10.22028/D291-35970
Title: Corneal Densitometry and In Vivo Confocal Microscopy in Patients with Monoclonal Gammopathy—Analysis of 130 Eyes of 65 Subjects
Author(s): Kormányos, Kitti
Kovács, Klaudia
Németh, Orsolya
Tóth, Gábor
Sándor, Gábor László
Csorba, Anita
Czakó, Cecília Nóra
Módis, László
Langenbucher, Achim
Nagy, Zoltán Zsolt
Varga, Gergely
Gopcsa, László
Mikala, Gábor
Szentmáry, Nóra
Language: English
Title: Journal of Clinical Medicine
Volume: 11
Issue: 7
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: monoclonal gammopathy
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Corneal imaging may support an early diagnosis of monoclonal gammopathy. The goal of our study was to analyze corneal stromal properties using Pentacam and in vivo confocal cornea microscopy (IVCM) in subjects with monoclonal gammopathy. Patients and methods: In our cross-sectional study, patients with monoclonal gammopathy (130 eyes of 65 patients (40.0% males; age 67.65 ± 9.74 years)) and randomly selected individuals of the same age group, without hematological disease (100 eyes of 50 control subjects (40.0% males; age 60.67 ± 15.06 years)) were included. Using Pentacam (Pentacam HR; Oculus GmbH, Wetzlar, Germany), corneal stromal light scattering values were obtained (1) centrally 0–2 mm zone; (2) 2–6 mm zone; (3) 6–10 mm zone; (4) 10–12 mm zone. Using IVCM with Heidelberg Retina Tomograph with Rostock Cornea Module (Heidelberg Engineering, Heidelberg, Germany), the density of hyperreflective keratocytes and the number of hyperreflective spikes per image were manually analyzed, in the stroma. Results: In the first, second and third annular zone, light scattering was significantly higher in subjects with monoclonal gammopathy, than in controls (p ≤ 0.04). The number of hyperreflective keratocytes and hyperreflective spikes per image was significantly higher in stroma of subjects with monoclonal gammopathy (p ≤ 0.012). Conclusions: Our study confirms that increased corneal light scattering in the central 10 mm annular zone and increased keratocyte hyperreflectivity may give rise to suspicion of monoclonal gammopathy. As corneal light scattering is not increased at the limbal 10–12 mm annular zone in monoclonal gammopathy subjects, our spatial analysis provides evidence against the limbal origin of corneal paraprotein deposition. Using IVCM, stromal hyperreflective spikes may represent specific signs of monoclonal gammopathy.
DOI of the first publication: 10.3390/jcm11071848
Link to this record: urn:nbn:de:bsz:291--ds-359700
ISSN: 2077-0383
Date of registration: 12-Apr-2022
Faculty: M - Medizinische Fakultät
Department: M - Augenheilkunde
Professorship: M - Univ.-Prof. Dr. Dipl.-Ing. Achim Langenbucher
M Prof. Dr. med. Nóra Szentmáry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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