Please use this identifier to cite or link to this item: doi:10.22028/D291-35968
Title: On the Connections between TRPM Channels and SOCE
Author(s): Souza Bomfim, Guilherme H.
Niemeyer, Barbara A.
Lacruz, Rodrigo S.
Lis, Annette
Language: English
Title: Cells
Volume: 11
Issue: 7
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: Ca2+ signaling
TRPM channels
ORAI channels
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Plasma membrane protein channels provide a passageway for ions to access the intracellular milieu. Rapid entry of calcium ions into cells is controlled mostly by ion channels, while Ca2+-ATPases and Ca2+ exchangers ensure that cytosolic Ca2+ levels ([Ca2+]cyt) are maintained at low (~100 nM) concentrations. Some channels, such as the Ca2+-release-activated Ca2+ (CRAC) channels and voltagedependent Ca2+ channels (CACNAs), are highly Ca2+-selective, while others, including the Transient Receptor Potential Melastatin (TRPM) family, have broader selectivity and are mostly permeable to monovalent and divalent cations. Activation of CRAC channels involves the coupling between ORAI1-3 channels with the endoplasmic reticulum (ER) located Ca2+ store sensor, Stromal Interaction Molecules 1-2 (STIM1/2), a pathway also termed store-operated Ca2+ entry (SOCE). The TRPM family is formed by 8 members (TRPM1-8) permeable to Mg2+, Ca2+, Zn2+ and Na+ cations, and is activated by multiple stimuli. Recent studies indicated that SOCE and TRPM structure-function are interlinked in some instances, although the molecular details of this interaction are only emerging. Here we review the role of TRPM and SOCE in Ca2+ handling and highlight the available evidence for this interaction.
DOI of the first publication: 10.3390/cells11071190
Link to this record: urn:nbn:de:bsz:291--ds-359683
ISSN: 2073-4409
Date of registration: 12-Apr-2022
Faculty: M - Medizinische Fakultät
Department: M - Biophysik
Professorship: M - Prof. Dr. Markus Hoth
M - Prof. Dr. Barbara Niemeyer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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