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Titel: Comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 PET/CT in Restaging of Prostate Cancer Patients with PSA Relapse
VerfasserIn: Hoffmann, Manuela A.
von Eyben, Finn Edler
Fischer, Nicolas
Rosar, Florian
Müller-Hübenthal, Jonas
Buchholz, Hans-Georg
Wieler, Helmut J.
Schreckenberger, Mathias
Sprache: Englisch
Titel: Cancers
Bandnummer: 14
Heft: 6
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: [ 18F]PSMA-1007 PET/CT
[68Ga]Ga-PSMA-11 PET/CT
prostate-specific antigen
prostate cancer
PSA threshold level
optimal PSA cut-off level
biochemical recurrence
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: This study aimed to compare the diagnostic performance of [18F]PSMA-1007 positron emission tomography/computed tomography (PET/CT) (18F-PSMA) and [68Ga]Ga-PSMA-11 PET/CT ( 68Ga-PSMA) by identifying prostate-specific antigen (PSA) threshold levels for optimal detecting recurrent prostate cancer (PC) and to compare both methods. Retrospectively, the study included 264 patients. The performances of 18F-PSMA and 68Ga-PSMA in relation to the pre-scan PSA were assessed by receiver operating characteristic (ROC) curve. 18F-PSMA showed PC-lesions in 87.5% (112/128 patients), while 68Ga-PSMA identified them in 88.9% (121/136). For 18F-PSMA biochemical recurrent (BCR) patients treated with radical prostatectomy (78/128, patient group: F-RP), a PSA of 1.08 ng/mL was found to be the optimal cut-off level for predicting positive and negative scans (AUC = 0.821; 95%, CI: 0.710–0.932), while for prostatectomized 68Ga-PSMA BCR-patients (89/136, patient group: Ga-RP), the cut-off was 1.84 ng/mL (AUC = 0.588; 95%, CI: 0.410–0.766). In patients with PSA < 1.08 ng/mL (F-RP) 76.3% and <1.84 ng/mL (Ga-RP) 78.6% scans were positive, whereas patients with PSA ≥ 1.08 ng/mL (F-RP) or 1.84 ng/mL (Ga-RP) had positive scan results in 100% and 91.5% (p < 0.001/p = 0.085). The identified PSA thresholds for PSMA-mappable PC lesions in BCR-patients (RP) showed a better separation for 18F-PSMA with regard to the distinguishing of positive and negative PC-lesions compared to 68Ga-PSMA. However, the two PSMA PET/CT tracers gave similar overall findings.
DOI der Erstveröffentlichung: 10.3390/cancers14061479
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-358393
hdl:20.500.11880/32686
http://dx.doi.org/10.22028/D291-35839
ISSN: 2072-6694
Datum des Eintrags: 29-Mär-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Radiologie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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