Please use this identifier to cite or link to this item: doi:10.22028/D291-35828
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Title: Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand
Author(s): Yang, Wenjuan
Denger, Andreas
Diener, Caroline Elisabeth
Küppers, Frederic
Soriano-Baguet, Leticia
Schäfer, Gertrud
Yanamandra, Archana K.
Zhao, Renping
Knörck, Arne
Schwarz, Eva C.
Hart, Martin
Lammert, Frank
Roma, Leticia Prates
Brenner, Dirk
Christidis, Grigorios
Helms, Volkhard
Meese, Eckart
Hoth, Markus
Qu, Bin
Language: English
Title: Frontiers in immunology
Volume: 13
Publisher/Platform: Frontiers
Year of Publication: 2022
Publikation type: Journal Article
Abstract: TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remains largely elusive. Here, we report that TRAIL is substantially up-regulated in CTLs in environments with high glucose (HG) both in vitro and in vivo. Non-mitochondrial reactive oxygen species, NFκB and PI3K/Akt are essential in HG-induced TRAIL upregulation in CTLs. TRAILhigh CTLs induce apoptosis of pancreatic beta cell line 1.4E7. Treatment with metformin and vitamin D reduces HG-enhanced expression of TRAIL in CTLs and coherently protects 1.4E7 cells from TRAIL-mediated apoptosis. Our work suggests that HG-induced TRAILhigh CTLs might contribute to the destruction of pancreatic beta cells in a hyperglycemia condition.
DOI of the first publication: 10.3389/fimmu.2022.831680
URL of the first publication: https://www.frontiersin.org/articles/10.3389/fimmu.2022.831680/full
Link to this record: hdl:20.500.11880/32662
http://dx.doi.org/10.22028/D291-35828
ISSN: 1664-3224
Date of registration: 24-Mar-2022
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Biophysik
M - Humangenetik
M - Innere Medizin
NT - Biowissenschaften
Professorship: M - Prof. Dr. Markus Hoth
M - Prof. Dr. Frank Lammert
M - Prof. Dr. Eckhart Meese
NT - Prof. Dr. Volkhard Helms
Collections:Die Universitätsbibliographie

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