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Titel: Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
VerfasserIn: Di Ciaula, Agostino
Bonfrate, Leonilde
Krawczyk, Marcin
Frühbeck, Gema
Portincasa, Piero
Sprache: Englisch
Titel: International Journal of Molecular Sciences
Bandnummer: 23
Heft: 5
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: liver steatosis
liver cirrhosis
binge drinking
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common liver disorders worldwide and the major causes of non-viral liver cirrhosis in the general population. In NAFLD, metabolic abnormalities, obesity, and metabolic syndrome are the driving factors for liver damage with no or minimal alcohol consumption. ALD refers to liver damage caused by excess alcohol intake in individuals drinking more than 5 to 10 daily units for years. Although NAFLD and ALD are nosologically considered two distinct entities, they show a continuum and exert synergistic effects on the progression toward liver cirrhosis. The current view is that low alcohol use might also increase the risk of advanced clinical liver disease in NAFLD, whereas metabolic factors increase the risk of cirrhosis among alcohol risk drinkers. Therefore, special interest is now addressed to individuals with metabolic abnormalities who consume small amounts of alcohol or who binge drink, for the role of light-to-moderate alcohol use in fibrosis progression and clinical severity of the liver disease. Evidence shows that in the presence of NAFLD, there is no liver-safe limit of alcohol intake. We discuss the epidemiological and clinical features of NAFLD/ALD, aspects of alcohol metabolism, and mechanisms of damage concerning steatosis, fibrosis, cumulative effects, and deleterious consequences which include hepatocellular carcinoma.
DOI der Erstveröffentlichung: 10.3390/ijms23052636
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-357247
hdl:20.500.11880/32570
http://dx.doi.org/10.22028/D291-35724
ISSN: 1422-0067
Datum des Eintrags: 11-Mär-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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