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Titel: Neural Crest Stem Cells in Juvenile Angiofibromas
VerfasserIn: Schick, Bernhard
Pillong, Lukas
Wenzel, Gentiana
Wemmert, Silke
Sprache: Englisch
Titel: International Journal of Molecular Sciences
Bandnummer: 23
Heft: 4
Verlag/Plattform: MDPI
Erscheinungsjahr: 2022
Freie Schlagwörter: juvenile angiofibroma
neural crest stem cell
CD271
epithelial-mesenchymal transition
MMP3
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The etiology of juvenile angiofibroma (JA) has been a controversial topic for more than 160 years. Numerous theories have been proposed to explain this rare benign neoplasm arising predominately in adolescent males, focusing mainly on either the vascular or fibrous component. To assess our hypothesis of JA’s being a malformation arising from neural crest cells/remnants of the first branchial arch plexus, we performed immunohistochemical analyses of neural crest stem cells (NCSC) and epithelial-mesenchymal transition (EMT) candidates. Immunoexpression of the NCSC marker CD271p75 was observed in all investigated JA’s (n = 22), mainly around the pathological vessels. Close to CD271p75-positive cells, high MMP3-staining was also observed. Additionally, from one JA with sufficient material, RT-qPCR identified differences in the expression pattern of PDGFRβ, MMP2 and MMP3 in MACS®-separated CD271p75positive vs. CD271p75 negative cell fractions. Our results, together with the consideration of the literature, provide evidence that JA’s represent a malformation within the first branchial arch artery/plexus remnants deriving from NCSC. This theory would explain the typical site of tumor origin as well as the characteristic tumor blood supply, whereas the process of EMT provides an explanation for the vascular and fibrous tumor component.
DOI der Erstveröffentlichung: 10.3390/ijms23041932
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-355921
hdl:20.500.11880/32502
http://dx.doi.org/10.22028/D291-35592
Datum des Eintrags: 1-Mär-2022
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Hals-Nasen-Ohrenheilkunde
Professur: M - Prof. Dr. Bernhard Schick
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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