Please use this identifier to cite or link to this item: doi:10.22028/D291-35480
Title: Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review
Author(s): Toledano, Manuel
Toledano-Osorio, Manuel
Hannig, Matthias
Carrasco-Carmona, Álvaro
Osorio, María T.
García-Godoy, Franklin
Cabello, Inmaculada
Osorio, Raquel
Language: English
Title: Polymers
Volume: 14
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: zinc
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, reminer alization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI and Web of Science. Through our search, we found literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules’ occlusion by crystals’ precipitation contributing to improved sealing efficacy of restorations. Loading dentin adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrix metalloproteinases (MMPs), contributing to dentin matrix stabilization. Zinc may not only act as a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin.
DOI of the first publication: 10.3390/polym14030642
Link to this record: urn:nbn:de:bsz:291--ds-354808
ISSN: 2073-4360
Date of registration: 18-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Zahn-, Mund- und Kieferheilkunde
Professorship: M - Prof. Dr. Matthias Hannig
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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