Please use this identifier to cite or link to this item: doi:10.22028/D291-35477
Title: Mitochondrial Genome Editing to Treat Human Osteoarthritis—A Narrative Review
Author(s): Zhong, Gang
Madry, Henning
Cucchiarini, Magali
Language: English
Title: International Journal of Molecular Sciences
Volume: 23
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: human osteoarthritis
mitochondrial DNA
genome editing
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Osteoarthritis (OA) is a severe, common chronic orthopaedic disorder characterised by a degradation of the articular cartilage with an incidence that increases over years. Despite the availability of various clinical options, none can stop the irreversible progression of the disease to definitely cure OA. Various mutations have been evidenced in the mitochondrial DNA (mtDNA) of cartilage cells (chondrocytes) in OA, leading to a dysfunction of the mitochondrial oxidative phos phorylation processes that significantly contributes to OA cartilage degeneration. The mitochondrial genome, therefore, represents a central, attractive target for therapy in OA, especially using genome editing procedures. In this narrative review article, we present and discuss the current advances and breakthroughs in mitochondrial genome editing as a potential, novel treatment to overcome mtDNA-related disorders such as OA. While still in its infancy and despite a number of challenges that need to be addressed (barriers to effective and site-specific mtDNA editing and repair), such a strategy has strong value to treat human OA in the future, especially using the groundbreaking clus tered regularly interspaced short palindromic repeats (CRIPSR)/CRISPR-associated 9 (CRISPR/Cas9) technology and mitochondrial transplantation approaches.
DOI of the first publication: 10.3390/ijms23031467
Link to this record: urn:nbn:de:bsz:291--ds-354774
ISSN: 1422-0067
Date of registration: 18-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
ijms-23-01467.pdf1,61 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons