Please use this identifier to cite or link to this item: doi:10.22028/D291-35473
Title: Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration
Author(s): Liu, Wei
Madry, Henning
Cucchiarini, Magali
Language: English
Title: International Journal of Molecular Sciences
Volume: 23
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: alginate
cell therapy
gene therapy
scaffold-guided gene transfer
cartilage regeneration
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials for cartilage repair and regeneration, allowing for the delivery of cells and therapeutic drugs and gene sequences. In light of the heterogeneity of findings reporting the benefits of using alginate for cartilage regeneration, a better understanding of alginate-based systems is needed in order to improve the approaches aiming to enhance cartilage regeneration with this compound. This review provides an in-depth evaluation of the literature, focusing on the manipulation of alginate as a tool to support the processes involved in cartilage healing in order to demonstrate how such a material, used as a direct compound or combined with cell and gene therapy and with scaffold-guided gene transfer procedures, may assist cartilage regeneration in an optimal manner for future applications in patients.
DOI of the first publication: 10.3390/ijms23031147
Link to this record: urn:nbn:de:bsz:291--ds-354739
ISSN: 1422-0067
Date of registration: 17-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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