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doi:10.22028/D291-35431
Titel: | Therapy of clinical stage IIA and IIB seminoma: a systematic review |
VerfasserIn: | Heinzelbecker, Julia Schmidt, Stefanie Lackner, Julia Busch, Jonas Bokemeyer, Carsten Classen, Johannes Dieing, Annette Hakenberg, Oliver Krege, Susanne Papachristofilou, Alexandros Pfister, David Ruf, Christian Schmelz, Hans Schmidberger, Heinz Souchon, Rainer Winter, Christian Zengerling, Friedemann Kliesch, Sabine Albers, Peter Oing, Christoph |
Sprache: | Englisch |
Titel: | World Journal of Urology |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Testicular cancer Seminoma CS IIA/B Systematic review Treatment Toxicity |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Purpose The optimal treatment for clinical stage (CS) IIA/IIB seminomas is still controversial. We evaluated current treatment options. Methods A systematic review was performed. Only randomized clinical trials and comparative studies published from January 2010 until February 2021 were included. Search items included: seminoma, CS IIA, CS IIB and therapy. Outcome parameters were relapse rate (RR), relapse-free (RFS), overall and cancer-specific survival (OS, CSS). Additionally, acute and long-term side effects including secondary malignancies (SMs) were analyzed. Results Seven comparative studies (one prospective and six retrospective) were identified with a total of 5049 patients (CS IIA: 2840, CS IIB: 2209). The applied treatment modalities were radiotherapy (RT) (n = 3049; CS IIA: 1888, CSIIB: 1006, unknown: 155) and chemotherapy (CT) or no RT (n = 2000; CS IIA: 797, CS IIB: 1074, unknown: 129). In CS IIA, RRs ranged from 0% to 4.8% for RT and 0% for CT. Concerning CS IIB RRs of 9.5%–21.1% for RT and of 0%–14.2% for CT have been reported. 5-year OS ranged from 90 to 100%. Only two studies reported on treatment-related toxicities. Conclusions RT and CT are the most commonly applied treatments in CS IIA/B seminoma. In CS IIA seminomas, RRs after RT and CT are similar. However, in CS IIB, CT seems to be more effective. Survival rates of CS IIA/B seminomas are excellent. Consequently, long-term toxicities and SMs are important survivorship issues. Alternative treatment approaches, e.g., retroperitoneal lymph node dissection (RPLND) or dose-reduced sequential CT/RT are currently under prospective investigation. |
DOI der Erstveröffentlichung: | 10.1007/s00345-021-03873-5 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-354313 hdl:20.500.11880/32355 http://dx.doi.org/10.22028/D291-35431 |
ISSN: | 1433-8726 0724-4983 |
Datum des Eintrags: | 8-Feb-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM1_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM2_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM3_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM4_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Heinzelbecker2021_Article_TherapyOfClinicalStageIIAAndII.pdf | 852,22 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons