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Titel: Therapy of clinical stage IIA and IIB seminoma: a systematic review
VerfasserIn: Heinzelbecker, Julia
Schmidt, Stefanie
Lackner, Julia
Busch, Jonas
Bokemeyer, Carsten
Classen, Johannes
Dieing, Annette
Hakenberg, Oliver
Krege, Susanne
Papachristofilou, Alexandros
Pfister, David
Ruf, Christian
Schmelz, Hans
Schmidberger, Heinz
Souchon, Rainer
Winter, Christian
Zengerling, Friedemann
Kliesch, Sabine
Albers, Peter
Oing, Christoph
Sprache: Englisch
Titel: World Journal of Urology
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2021
Freie Schlagwörter: Testicular cancer
Seminoma
CS IIA/B
Systematic review
Treatment
Toxicity
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Purpose The optimal treatment for clinical stage (CS) IIA/IIB seminomas is still controversial. We evaluated current treatment options. Methods A systematic review was performed. Only randomized clinical trials and comparative studies published from January 2010 until February 2021 were included. Search items included: seminoma, CS IIA, CS IIB and therapy. Outcome parameters were relapse rate (RR), relapse-free (RFS), overall and cancer-specific survival (OS, CSS). Additionally, acute and long-term side effects including secondary malignancies (SMs) were analyzed. Results Seven comparative studies (one prospective and six retrospective) were identified with a total of 5049 patients (CS IIA: 2840, CS IIB: 2209). The applied treatment modalities were radiotherapy (RT) (n = 3049; CS IIA: 1888, CSIIB: 1006, unknown: 155) and chemotherapy (CT) or no RT (n = 2000; CS IIA: 797, CS IIB: 1074, unknown: 129). In CS IIA, RRs ranged from 0% to 4.8% for RT and 0% for CT. Concerning CS IIB RRs of 9.5%–21.1% for RT and of 0%–14.2% for CT have been reported. 5-year OS ranged from 90 to 100%. Only two studies reported on treatment-related toxicities. Conclusions RT and CT are the most commonly applied treatments in CS IIA/B seminoma. In CS IIA seminomas, RRs after RT and CT are similar. However, in CS IIB, CT seems to be more effective. Survival rates of CS IIA/B seminomas are excellent. Consequently, long-term toxicities and SMs are important survivorship issues. Alternative treatment approaches, e.g., retroperitoneal lymph node dissection (RPLND) or dose-reduced sequential CT/RT are currently under prospective investigation.
DOI der Erstveröffentlichung: 10.1007/s00345-021-03873-5
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-354313
hdl:20.500.11880/32355
http://dx.doi.org/10.22028/D291-35431
ISSN: 1433-8726
0724-4983
Datum des Eintrags: 8-Feb-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Information
In Beziehung stehendes Objekt: https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM1_ESM.docx
https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM2_ESM.docx
https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM3_ESM.docx
https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-021-03873-5/MediaObjects/345_2021_3873_MOESM4_ESM.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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