Please use this identifier to cite or link to this item: doi:10.22028/D291-35424
Title: Vascular Response on a Novel Fibrin-Based Coated Flow Diverter
Author(s): Mühl-Benninghaus, Ruben
Fries, Frederik
Kießling, Mara
Tomori, Toshiki
Krajewski, Stefanie
Simgen, Andreas
Bauer, Sabina
Hey, Natascha
Brynda, Eduard
Taborska, Johanka
Riedel, Tomáš
Reith, Wolfgang
Cattaneo, Giorgio
Brochhausen, Christoph
Language: English
Title: Cardiovascular and Interventional Radiology
Volume: 45
Issue: 2
Pages: 236–243
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Flow diverter
Surface modification
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Purpose Due to thromboembolic complications and in-stent-stenosis after flow diverter (FD) treatment, the long-term use of dual antiplatelet treatment (DAPT) is mandatory. The tested nano-coating has been shown to reduce material thrombogenicity and promote endothelial cell proliferation in vitro. We compared the biocompatibility of coated (Derivo Heal) and non-coated (Derivo bare) FDs with DAPT in an animal model. Methods Derivo® bare (n = 10) and Derivo® Heal (n = 10) FD were implanted in the common carotid arteries (CCAs) of New Zealand white rabbits. One additional FD, alternately a Derivo bare (n = 5) or Derivo Heal (n = 5), was implanted in the abdominal aorta (AA) for assessment of the patency of branch arteries. Histopathological examinations were performed after 28 days. Angiography was performed before and after FD implantation and at follow-up. Results Statistical analysis of the included specimens showed complete endothelialization of all FDs with no significant differences in neointima thickness between Derivo® bare and Derivo® Heal (CCA: p = 0.91; AA: p = 0.59). A significantly reduced number of macrophages in the vessel wall of the Derivo Heal was observed for the CCA (p = 0.02), and significantly reduced fibrin and platelet deposition on the surface of the Derivo Heal was observed for the AA. All branch arteries of the stented aorta remained patent. Conclusion In this animal model, the novel fibrin-based coated FD showed a similar blood and tissue compatibility as the non-coated FD.
DOI of the first publication: 10.1007/s00270-021-03007-9
Link to this record: urn:nbn:de:bsz:291--ds-354249
ISSN: 1432-086X
Date of registration: 7-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Radiologie
Professorship: M - Prof. Dr. Wolfgang Reith
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
Mühl-Benninghaus2022_Article_VascularResponseOnANovelFibrin.pdf556,12 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons