Please use this identifier to cite or link to this item: doi:10.22028/D291-35423
Title: ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose-results after 3 months' follow-up
Author(s): Niewald, Marcus
Müller, Lara Natalie
Hautmann, Matthias G.
Dzierma, Yvonne
Melchior, Patrick
Gräber, Stefan
Rübe, Christian
Fleckenstein, Jochen
Language: English
Title: Strahlentherapie und Onkologie
Publisher/Platform: Springer Nature
Year of Publication: 2021
Free key words: Osteoarthritis
Low dose
Pain relief
Quality of life
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Purpose Randomized comparison of the effect of radiotherapy on painful osteoarthritis (OA) applying a standard-dose vs. a very-low-dose regime Patients and methods Patients with OA of the hand and knee joints were included. Further inclusion criteria: symptoms for more than 3 months, favorable general health status, age above 40 years. Patients with prior local radiotherapy, trauma, rheumatoid arthritis, or vascular diseases were excluded. After randomization (every joint was randomized separately), the following protocols were applied: standard arm: total dose 3.0 Gy, single fractions of 0.5 Gy twice weekly; experimental arm: total dose 0.3 Gy, single fractions of 0.05 Gy twice weekly. The dosage was not known to the patients. The patients were examined 3 and 12 months after radiotherapy. Scores like VAS (visual analogue scale), KOOS-SF (the knee injugy and osteoarthritis outcome score), SF-SACRAH (short form score for the assessment and quantification of chronic rheumatic affections of the hands), and SF-12 (short form 12) were used. Results A total of 64 knees and 172 hands were randomized. 3.0 Gy was applied to 87 hands and 34 knees, 0.3 Gy was given to 85 hands and 30 knees. After 3 months, we observed good pain relief after 3 Gy and after 0.3 Gy, there was no statistically significant difference. Side effects were not recorded. The trial was closed prematurely due to slow recruitment. Conclusion We found favorable pain relief and a limited response in the functional and quality of life scores in both arms. The effect of low doses such as 0.3 Gy on pain is widely unknown. Further trials are necessary to compare a conventional dose to placebo and to further explore the effect of low doses on inflammatory disorders.
DOI of the first publication: 10.1007/s00066-021-01866-2
Link to this record: urn:nbn:de:bsz:291--ds-354239
ISSN: 1439-099X
Date of registration: 7-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Neurochirurgie
M - Radiologie
Professorship: M - Prof. Dr. Joachim Oertel
M - Prof. Dr. Christian Rübe
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
Niewald2021_Article_ArthroRadTrialMulticentricPros.pdf821,29 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons