Please use this identifier to cite or link to this item: doi:10.22028/D291-35362
Title: Orchestration of tissue-scale mechanics and fate decisions by polarity signalling
Author(s): Dias Gomes, Martim
Iden, Sandra
Language: English
Title: The EMBO Journal
Volume: 40
Issue: 12
Publisher/Platform: Wiley
Year of Publication: 2021
Free key words: cell fate
cell mechanics
cell polarity
polarity proteins
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Eukaryotic development relies on dynamic cell shape changes and segregation of fate determinants to achieve coordinated compartmentalization at larger scale. Studies in invertebrates have identified polarity programmes essential for morphogenesis; however, less is known about their contribution to adult tissue maintenance. While polarity-dependent fate decisions in mammals utilize molecular machineries similar to invertebrates, the hierarchies and effectors can differ widely. Recent studies in epithelial systems disclosed an intriguing interplay of polarity proteins, adhesion molecules and mechanochemical pathways in tissue organization. Based on major advances in biophysics, genome editing, highresolution imaging and mathematical modelling, the cell polarity field has evolved to a remarkably multidisciplinary ground. Here, we review emerging concepts how polarity and cell fate are coupled, with emphasis on tissue-scale mechanisms, mechanobiology and mammalian models. Recent findings on the role of polarity signalling for tissue mechanics, micro-environmental functions and fate choices in health and disease will be summarized.
DOI of the first publication: 10.15252/embj.2020106787
Link to this record: urn:nbn:de:bsz:291--ds-353621
ISSN: 1460-2075
Date of registration: 1-Feb-2022
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
Professorship: M - Univ.-Prof. Dr. Sandra Iden
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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