Please use this identifier to cite or link to this item: doi:10.22028/D291-35360
Title: Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results
Author(s): Hauser, Ingeborg A.
Marx, Stefanie
Sommerer, Claudia
Suwelack, Barbara
Dragun, Duska
Witzke, Oliver
Lehner, Frank
Schiedel, Christiane
Porstner, Martina
Thaiss, Friedrich
Neudörfl, Christine
Falk, Christine S.
Nashan, Björn
Sester, Martina
Language: English
Title: European Journal of Immunology
Volume: 51
Issue: 4
Pages: 943–955
Publisher/Platform: Wiley
Year of Publication: 2020
Free key words: CMV
CD4 T cells
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Post-transplant cytomegalovirus (CMV) infections and increased viral replication are associated with CMV-specific T-cell anergy. In the ATHENA-study, de-novo everolimus (EVR) with reduced-exposure tacrolimus (TAC) or cyclosporine (CyA) showed significant benefit in preventing CMV infections in renal transplant recipients as compared to standard TAC + mycophenolic acid (MPA). However, immunomodulatory mechanisms for this effect remain largely unknown. Ninety patients from the ATHENA-study completing the 12-month visit on-treatment (EVR + TAC n = 28; EVR + CyA n = 19; MPA + TAC n = 43) were included in a posthoc analysis. Total lymphocyte subpopulations were quantified. CMV-specific CD4 T cells were determined after stimulation with CMV-antigen, and cytokine-profiles and various T-cell anergy markers were analyzed using flow cytometry. While 25.6% of MPA + TAC-treated patients had CMV-infections, no such events were reported in EVR-treated patients. Absolute numbers of lymphocyte subpopulations were comparable between arms, whereas the percentage of regulatory T cells was significantly higher with EVR + CyA versus MPA + TAC (p = 0.019). Despite similar percentages of CMV-specific T cells, their median expression of CTLA-4 and PD-1 was lower with EVR + TAC (p < 0.05 for both) or EVR + CyA (p = 0.045 for CTLA-4) compared with MPA + TAC. Moreover, mean percentages of multifunctional CMV-specific T cells were higher with EVR + TAC (27.2%) and EVR + CyA (29.4%) than with MPA + TAC (19.0%). In conclusion, EVR-treated patients retained CMV-specific T-cell functionality, which may contribute to enhanced protection against CMV infections.
DOI of the first publication: 10.1002/eji.202048855
Link to this record: urn:nbn:de:bsz:291--ds-353605
ISSN: 1521-4141
Date of registration: 1-Feb-2022
Description of the related object: Supporting Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
Professorship: M - Prof. Dr. Martina Sester
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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