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Titel: Chemoradiotherapy-induced increase in Th17 cell frequency in cervical cancer patients is associated with therapy resistance and early relapse
VerfasserIn: Theobald, Laura
Stroeder, Russalina
Melchior, Patrick
Iordache, Ioan Iulian
Tänzer, Tanja
Port, Meike
Glombitza, Birgit
Marx, Stefanie
Schub, David
Herr, Christian
Hart, Martin
Ludwig, Nicole
Meese, Eckart
Kim, Yoo-Jin
Bohle, Rainer Maria
Smola, Sigrun
Rübe, Christian
Solomayer, Erich Franz
Walch-Rückheim, Barbara
Sprache: Englisch
Titel: Molecular Oncology
Bandnummer: 15
Heft: 12
Seiten: 3559–3577
Verlag/Plattform: FEBS
Erscheinungsjahr: 2021
Freie Schlagwörter: AKT
cervical cancer recurrence
chemoradiotherapy
resistance
T-helper-17 cells
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Cervical cancer therapy is still a major clinical challenge, as patients substantially differ in their response to standard treatments, including chemoradiotherapy (CRT). During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients and are associated with poor prognosis. In this prospective study, we find increased Th17 frequencies in the blood of patients after chemoradiotherapy and a post-therapeutic ratio of Th17/CD4+ T cells > 8% was associated with early recurrence. Furthermore, Th17 cells promote resistance of cervical cancer cells toward CRT, which was dependent on the AKT signaling pathway. Consistently, patients with high Th17 frequencies in pretherapeutic biopsies exhibit lower response to primary CRT. This work reveals a key role of Th17 cells in CRT resistance and elevated Th17 frequencies in the blood after CRT correspond with early recurrence. Our results may help to explain individual treatment responses of cervical cancer patients and suggest evaluation of Th17 cells as a novel predictive biomarker for chemoradiotherapy responses and as a potential target for immunotherapy in cervical cancer.
DOI der Erstveröffentlichung: 10.1002/1878-0261.13095
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-353249
hdl:20.500.11880/32229
http://dx.doi.org/10.22028/D291-35324
ISSN: 1878-0261
1574-7891
Datum des Eintrags: 25-Jan-2022
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0001-FigS1.pdf
https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0002-FigS2.pdf
https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0003-FigS3.pdf
https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0004-FigS4.pdf
https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0005-FigS5.pdf
https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0006-FigS6.pdf
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Frauenheilkunde
M - Humangenetik
M - Infektionsmedizin
Professur: M - Prof. Dr. Eckhart Meese
M - Prof. Dr. Sigrun Smola
M - Prof. Dr. E.-F. Solomayer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons