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doi:10.22028/D291-35324
Titel: | Chemoradiotherapy-induced increase in Th17 cell frequency in cervical cancer patients is associated with therapy resistance and early relapse |
VerfasserIn: | Theobald, Laura Stroeder, Russalina Melchior, Patrick Iordache, Ioan Iulian Tänzer, Tanja Port, Meike Glombitza, Birgit Marx, Stefanie Schub, David Herr, Christian Hart, Martin Ludwig, Nicole Meese, Eckart Kim, Yoo-Jin Bohle, Rainer Maria Smola, Sigrun Rübe, Christian Solomayer, Erich Franz Walch-Rückheim, Barbara |
Sprache: | Englisch |
Titel: | Molecular Oncology |
Bandnummer: | 15 |
Heft: | 12 |
Seiten: | 3559–3577 |
Verlag/Plattform: | FEBS |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | AKT cervical cancer recurrence chemoradiotherapy resistance T-helper-17 cells |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Cervical cancer therapy is still a major clinical challenge, as patients substantially differ in their response to standard treatments, including chemoradiotherapy (CRT). During cervical carcinogenesis, T-helper (Th)-17 cells accumulate in the peripheral blood and tumor tissues of cancer patients and are associated with poor prognosis. In this prospective study, we find increased Th17 frequencies in the blood of patients after chemoradiotherapy and a post-therapeutic ratio of Th17/CD4+ T cells > 8% was associated with early recurrence. Furthermore, Th17 cells promote resistance of cervical cancer cells toward CRT, which was dependent on the AKT signaling pathway. Consistently, patients with high Th17 frequencies in pretherapeutic biopsies exhibit lower response to primary CRT. This work reveals a key role of Th17 cells in CRT resistance and elevated Th17 frequencies in the blood after CRT correspond with early recurrence. Our results may help to explain individual treatment responses of cervical cancer patients and suggest evaluation of Th17 cells as a novel predictive biomarker for chemoradiotherapy responses and as a potential target for immunotherapy in cervical cancer. |
DOI der Erstveröffentlichung: | 10.1002/1878-0261.13095 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-353249 hdl:20.500.11880/32229 http://dx.doi.org/10.22028/D291-35324 |
ISSN: | 1878-0261 1574-7891 |
Datum des Eintrags: | 25-Jan-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0001-FigS1.pdf https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0002-FigS2.pdf https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0003-FigS3.pdf https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0004-FigS4.pdf https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0005-FigS5.pdf https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1878-0261.13095&file=mol213095-sup-0006-FigS6.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Frauenheilkunde M - Humangenetik M - Infektionsmedizin |
Professur: | M - Prof. Dr. Eckhart Meese M - Prof. Dr. Sigrun Smola M - Prof. Dr. E.-F. Solomayer |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Molecular Oncology - 2021 - Theobald - Chemoradiotherapy‐induced increase in Th17 cell frequency in cervical cancer.pdf | 2,42 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons