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doi:10.22028/D291-35176
Titel: | Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress |
VerfasserIn: | Vilas-Boas, Eloisa Aparecida Almeida, Davidson Correa Roma, Leticia Prates Ortis, Fernanda Carpinelli, Angelo Rafael |
Sprache: | Englisch |
Titel: | Cells |
Bandnummer: | 10 |
Heft: | 12 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | lipotoxicity pancreatic β-cell type 2 diabetes NADPH oxidase oxidative stress ER stress |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | A high caloric intake, rich in saturated fats, greatly contributes to the development of obesity, which is the leading risk factor for type 2 diabetes (T2D). A persistent caloric surplus increases plasma levels of fatty acids (FAs), especially saturated ones, which were shown to negatively impact pancreatic β-cell function and survival in a process called lipotoxicity. Lipotoxicity in β cells activates different stress pathways, culminating in β-cells dysfunction and death. Among all stresses, endoplasmic reticulum (ER) stress and oxidative stress have been shown to be strongly correlated. One main source of oxidative stress in pancreatic β-cells appears to be the reactive oxygen species producer NADPH oxidase (NOX) enzyme, which has a role in the glucose-stimulated insulin secretion and in the β-cell demise during both T1 and T2D. In this review, we focus on the acute and chronic effects of FAs and the lipotoxicity-induced β-cell failure during T2D development, with special emphasis on the oxidative stress induced by NOX, the ER stress, and the crosstalk between NOX and ER stress. |
DOI der Erstveröffentlichung: | 10.3390/cells10123328 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-351760 hdl:20.500.11880/32150 http://dx.doi.org/10.22028/D291-35176 |
ISSN: | 2073-4409 |
Datum des Eintrags: | 7-Jan-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Biophysik |
Professur: | M - Dr. Leticia Prates Roma |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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cells-10-03328.pdf | 3,51 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons