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Titel: Engineered living biomaterials
VerfasserIn: Rodrigo-Navarro, Aleixandre
Sankaran, Shrikrishnan
Dalby, Matthew J.
del Campo Bécares, Aránzazu
Salmeron-Sanchez, Manuel
Sprache: Englisch
Titel: Nature reviews
Bandnummer: 6
Heft: 12
Startseite: 1175
Endseite: 1190
Verlag/Plattform: Nature Publishing Group
Erscheinungsjahr: 2021
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Biomaterials have evolved from inert materials that lack interaction with the body to biologically active, instructive materials that host and provide signals to surrounding cells and tissues. Engineered living materials contain living cells (responsive function) and polymeric matrices (scaffolding function) and, thus, can be designed as active and response biomaterials. In this Review, we discuss engineered living materials that incorporate microorganisms as the living, bioactive component. Microorganisms can provide complex responses to environmental stimuli, and they can be genetically engineered to allow user control over responses and integration of numerous inputs. The engineered microorganisms can either generate their own matrix, such as in biofilms, or they can be incorporated in matrices using various technologies, such as coating, 3D printing, spinning and microencapsulation. We highlight biomedical applications of such engineered living materials, including biosensing, wound healing, stem-cell-based tissue engineering and drug delivery, and provide an outlook to the challenges and future applications of engineered living materials.
DOI der Erstveröffentlichung: 10.1038/s41578-021-00350-8
URL der Erstveröffentlichung: https://www.nature.com/articles/s41578-021-00350-8
Link zu diesem Datensatz: hdl:20.500.11880/32100
http://dx.doi.org/10.22028/D291-34693
ISSN: 2058-8437
Datum des Eintrags: 22-Dez-2021
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Chemie
Professur: NT - Prof. Dr. Aránzazu del Campo
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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