Please use this identifier to cite or link to this item: doi:10.22028/D291-35039
Title: Impact of Vitamin D3 Deficiency on Phosphatidylcholine-/Ethanolamine, Plasmalogen-, Lyso-Phosphatidylcholine-/Ethanolamine, Carnitine- and Triacyl Glyceride-Homeostasis in Neuroblastoma Cells and Murine Brain
Author(s): Lauer, Anna Andrea
Griebsch, Lea Victoria
Pilz, Sabrina Melanie
Janitschke, Daniel
Theiss, Elena Leoni
Reichrath, Jörg
Herr, Christian
Beisswenger, Christoph
Bals, Robert
Valencak, Teresa Giovanna
Portius, Dorothea
Grimm, Heike Sabine
Hartmann, Tobias
Grimm, Marcus Otto Walter
Language: English
Title: Biomolecules
Volume: 11
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: vitamin D hypovitaminosis
shotgun lipidomics
neurodegenerative diseases
phosphatidylcholine plasmalogen
triacyl glyceride
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Vitamin D3 hypovitaminosis is associated with several neurological diseases such as Alzheimer’s disease, Parkinson’s disease or multiple sclerosis but also with other diseases such as cancer, diabetes or diseases linked to inflammatory processes. Importantly, in all of these dis eases lipids have at least a disease modifying effect. Besides its well-known property to modulate gene-expression via the VDR-receptor, less is known if vitamin D hypovitaminosis influences lipid homeostasis and if these potential changes contribute to the pathology of the diseases themselves. Therefore, we analyzed mouse brain with a mild vitamin D hypovitaminosis via a targeted shotgun lipidomic approach, including phosphatidylcholine, plasmalogens, lyso-phosphatidylcholine, (acyl- /acetyl-) carnitines and triglycerides. Alterations were compared with neuroblastoma cells cultivated in the presence and with decreased levels of vitamin D. Both in cell culture and in vivo, decreased vitamin D level resulted in changed lipid levels. While triglycerides were decreased, carnitines were increased under vitamin D hypovitaminosis suggesting an impact of vitamin D on energy metabolism. Additionally, lyso-phosphatidylcholines in particular saturated phosphatidylcholine (e.g., PC aa 48:0) and plasmalogen species (e.g., PC ae 42:0) tended to be increased. Our results suggest that vitamin D hypovitaminosis not only may affect gene expression but also may directly influence cellular lipid homeostasis and affect lipid turnover in disease states that are known for vitamin D hypovitaminosis.
DOI of the first publication: 10.3390/biom11111699
Link to this record: urn:nbn:de:bsz:291--ds-350397
ISSN: 2218-273X
Date of registration: 13-Dec-2021
Description of the related object: Supplementary Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Dermatologie
M - Innere Medizin
M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Robert Bals
M - Prof. Dr. Tobias Hartmann
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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