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Titel: Reliable release testing for nanoparticles with the NanoDis System, an innovative sample and separate technique
VerfasserIn: Lombardo, Sonia M.
Günday Türeli, Nazende
Koch, Marcus
Schneider, Marc
Türeli, Akif E.
Sprache: Englisch
Titel: International journal of pharmaceutics
Bandnummer: 609
Verlag/Plattform: Elsevier
Erscheinungsjahr: 2021
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: One of the critical quality attributes of nanoparticle formulations is drug release. Their release properties should therefore be well characterized with predictive and discriminative methods. However, there is presently still no standard method for the release testing of extended release nanoformulations. Dialysis techniques are widely used in the literature but suffer from severe drawbacks. Burst release of formulations can be masked by slow permeation kinetics of the free drug through the dialysis membrane, saturation in the membrane, and absence of agitation in the membrane. In this study, the release profile of poly(lactic co-glycolic) (PLGA) nanocapsules loaded with all-trans retinoic acid was characterized using an innovative sample and separate set-up, the NanoDis System, and compared to the release profile measured with a dialysis technique. The NanoDis System showed clear superiority over the dialysis method and was able to accurately characterize the burst release from the capsules and furthermore discriminate between different all-trans retinoic acid nanoparticle formulations.
DOI der Erstveröffentlichung: 10.1016/j.ijpharm.2021.121215
URL der Erstveröffentlichung: https://www.sciencedirect.com/science/article/pii/S0378517321010218
Link zu diesem Datensatz: hdl:20.500.11880/32002
http://dx.doi.org/10.22028/D291-35068
ISSN: 1873-3476
0378-5173
Datum des Eintrags: 6-Dez-2021
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Marc Schneider
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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