Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
doi:10.22028/D291-34886
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
molecules-26-06097-v2.pdf | 1,3 MB | Adobe PDF | Öffnen/Anzeigen |
Titel: | Nicotinic Acetylcholine Receptors in the Respiratory Tract |
VerfasserIn: | Hollenhorst, Monika I. Krasteva-Christ, Gabriela ![]() |
Sprache: | Englisch |
In: | |
Titel: | Molecules |
Bandnummer: | 26 |
Heft: | 20 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | nicotinic acetylcholine receptors airways lung respiratory tract mucociliary clearance chronic obstructive pulmonary disease asthma lung cancer |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Nicotinic acetylcholine receptors (nAChR) are widely distributed in neuronal and nonneuronal tissues, where they play diverse physiological roles. In this review, we highlight the recent findings regarding the role of nAChR in the respiratory tract with a special focus on the involvement of nAChR in the regulation of multiple processes in health and disease. We discuss the role of nAChR in mucociliary clearance, inflammation, and infection and in airway diseases such as asthma, chronic obstructive pulmonary disease, and cancer. The subtype diversity of nAChR enables differential regulation, making them a suitable pharmaceutical target in many diseases. The stimulation of the α3β4 nAChR could be beneficial in diseases accompanied by impaired mucociliary clearance, and the anti-inflammatory effect due to an α7 nAChR stimulation could alleviate symptoms in diseases with chronic inflammation such as chronic obstructive pulmonary disease and asthma, while the inhibition of the α5 nAChR could potentially be applied in non-small cell lung cancer treatment. However, while clinical studies targeting nAChR in the airways are still lacking, we suggest that more detailed research into this topic and possible pharmaceutical applications could represent a valuable tool to alleviate the symptoms of diverse airway diseases. |
DOI der Erstveröffentlichung: | 10.3390/molecules26206097 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-348867 hdl:20.500.11880/31914 http://dx.doi.org/10.22028/D291-34886 |
ISSN: | 1420-3049 |
Datum des Eintrags: | 27-Okt-2021 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Anatomie und Zellbiologie |
Professur: | M - Prof. Dr. Gabriela Krasteva-Christ |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons