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doi:10.22028/D291-34883
Titel: | Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas |
VerfasserIn: | Hartmann, Sylvia Scharf, Sonja Steiner, Yvonne Loth, Andreas G. Donnadieu, Emmanuel Flinner, Nadine Poeschel, Viola Angel, Stephanie Bewarder, Moritz Bein, Julia Brunnberg, Uta Bozzato, Alessandro Schick, Bernhard Stilgenbauer, Stephan Bohle, Rainer M. Thurner, Lorenz Hansmann, Martin-Leo |
Sprache: | Englisch |
Titel: | Cancers |
Bandnummer: | 13 |
Heft: | 20 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | migration cell motility cell contacts Hodgkin lymphoma non-Hodgkin lymphoma |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Profound knowledge exists about the clinical, morphologic, genomic, and transcriptomic characteristics of most lymphoma entities. However, information is currently lacking on the dynamic behavior of malignant lymphomas. This pilot study aimed to gain insight into the motility of malignant lymphomas and bystander cells in 20 human lymph nodes. Generally, B cells were faster under reactive conditions compared with B cells in malignant lymphomas. In contrast, PD1-positive T cells did not show systematic differences in velocity between reactive and neoplastic conditions in general. However, lymphomas could be divided into two groups: one with fast PD1-positive T cells (e.g., Hodgkin lymphoma and mantle cell lymphoma; means 8.4 and 7.8 µm/min) and another with slower PD1-positive T cells (e.g., mediastinal grey zone lymphoma; mean 3.5 µm/min). Although the number of contacts between lymphoma cells and PD1-positive T cells was similar in different lymphoma types, important differences were observed in the duration of these contacts. Among the lymphomas with fast PD1-positive T cells, contacts were particularly short in mantle cell lymphoma (mean 54 s), whereas nodular lymphocyte-predominant Hodgkin lymphoma presented prolonged contact times (mean 6.1 min). Short contact times in mantle cell lymphoma were associated with the largest spatial displacement of PD1-positive cells (mean 12.3 µm). Although PD1-positive T cells in nodular lymphocyte-predominant Hodgkin lymphoma were fast, they remained in close contact with the lymphoma cells, in line with a dynamic immunological synapse. This pilot study shows for the first time systematic differences in the dynamic behavior of lymphoma and bystander cells between different lymphoma types. |
DOI der Erstveröffentlichung: | 10.3390/cancers13205208 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-348836 hdl:20.500.11880/31908 http://dx.doi.org/10.22028/D291-34883 |
ISSN: | 2072-6694 |
Datum des Eintrags: | 27-Okt-2021 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Material |
In Beziehung stehendes Objekt: | https://www.mdpi.com/2072-6694/13/20/5208/s1 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Hals-Nasen-Ohrenheilkunde M - Innere Medizin M - Pathologie |
Professur: | M - Prof. Dr. Rainer M. Bohle M - Prof. Dr. Bernhard Schick M - Prof. Dr. Stephan Stilgenbauer M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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cancers-13-05208-v2.pdf | 2,43 MB | Adobe PDF | Öffnen/Anzeigen |
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