Please use this identifier to cite or link to this item: doi:10.22028/D291-34856
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Title: Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations
Author(s): Moreira Lana, Gabriela
Sorg, Katharina
Wenzel, Gentiana Ioana
Hecker, Dietmar
Hensel, René
Schick, Bernhard
Kruttwig, Klaus
Arzt, Eduard
Language: English
Title: Advanced nanoBiomed research
Volume: 1
Issue: 10
Publisher/Platform: Wiley
Year of Publication: 2021
Publikation type: Journal Article
Abstract: Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations.
DOI of the first publication: 10.1002/anbr.202100057
URL of the first publication: https://onlinelibrary.wiley.com/doi/full/10.1002/anbr.202100057
Link to this record: hdl:20.500.11880/31867
http://dx.doi.org/10.22028/D291-34856
ISSN: 2699-9307
Date of registration: 19-Oct-2021
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Materialwissenschaft und Werkstofftechnik
Professorship: NT - Prof. Dr. Eduard Arzt
Collections:Die Universitätsbibliographie

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