Please use this identifier to cite or link to this item: doi:10.22028/D291-34585
Title: Response Assessment and Prediction of Progression-Free Survival by 68Ga-PSMA-11 PET/CT Based on Tumor-to-Liver Ratio (TLR) in Patients with mCRPC Undergoing 177Lu-PSMA-617 Radioligand Therapy
Author(s): Khreish, Fadi
Wiessner, Mona
Rosar, Florian
Ghazal, Zaidoon
Sabet, Amir
Maus, Stephan
Linxweiler, Johannes
Bartholomä, Mark
Ezziddin, Samer
Language: English
Title: Biomolecules
Volume: 11
Issue: 8
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: metastatic castration-resistant prostate cancer (mCRPC)
radioligand therapy
molecular imaging-based response assessment
tumor-toliver ratio (TLR)
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: At present, little is known about the molecular imaging-based response assessment of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy with 177Lutetium (177LuPSMA-617 RLT) in metastatic castration-resistant prostate cancer (mCRPC). Our study evaluated the response to RLT using both molecular imaging and biochemical response assessments, and their potential prediction of progression-free survival (PFS). Fifty-one consecutive patients given two cycles of RLT at 6-week intervals were analyzed retrospectively. 68Ga-PSMA-11 PET/CT was obtained about 2 weeks prior to the first and 4–6 weeks after the second cycle. Molecular imaging-based response using SUVpeak and tumor-to-liver ratio (TLR) was determined by modified PERCIST criteria. ∆TLR and ∆SUV were significantly correlated with ∆PSA (p < 0.001, each). After a median follow-up of 49 months, the median PFS (95% CI) was 8.0 (5.9–10.1) months. In univariate analysis, responders showing partial remission (PRPSA and PRTLR) had significantly (p < 0.001, each) longer PFS (median: 10.5 and 9.3 months) than non-responders showing either stable or progressive disease (median: 4.0 and 3.5 months). Response assessment using SUVpeak failed to predict survival. In multivariable analysis, response assessment using TLR was independently associated with PFS (p < 0.001), as was good performance status (p = 0.002). Molecular imaging-based response assessment with 68Ga-PSMA11 PET/CT using normalization of the total lesion PSMA over healthy liver tissue uptake (TLR) could be an appropriate biomarker to monitor RLT in mCRPC patients and to predict progression-free survival (PFS) of this treatment modality
DOI of the first publication: 10.3390/biom11081099
Link to this record: urn:nbn:de:bsz:291--ds-345854
ISSN: 2218-273X
Date of registration: 27-Aug-2021
Faculty: M - Medizinische Fakultät
Department: M - Radiologie
M - Urologie und Kinderurologie
Professorship: M - Prof. Dr. Samer Ezziddin
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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