Please use this identifier to cite or link to this item: doi:10.22028/D291-34580
Title: SOX2 and Bcl-2 as a Novel Prognostic Value in Hepatocellular Carcinoma Progression
Author(s): Hosseini-khah, Zahra
Babaei, Mohammad Reza
Tehrani, Mohsen
Cucchiarini, Magali
Madry, Henning
Ajami, Abolghasem
Rakhshani, Nasser
Rafiei, Alireza
Nikbin, Behrooz
Language: English
Title: Current Oncology
Volume: 28
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: SRY-box 2 (SOX2)
cancer stem cell
hepatocellular carcinoma
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Sex-determining region Y-box 2 (SOX2) is a stem cell transcription factor and a major regulator of self-renewal and pluripotency of cancer stem cells (CSCs). In many types of cancer, SOX2 is dysregulated due to overexpression associated with tumor progression and low survival rate. Many HCC cases encounter recurrence and metastasis which might be due to CSCs and also apoptosis. Since little is known about the expression pattern of SOX2 and apoptotic genes in HCC, we aimed to determine the prognostic significance of SOX2, Bax, and Bcl-2 in clinicopathological features, tumor progression, and survival rate of the HCC patients. The expression of SOX2, Bax, and Bcl-2 were evaluated using qRT-PCR in 53 formalin-fixed, paraffin-embedded tissues (FFPE) of patients and 44 controls. Correlation of these genes was analyzed with clinicopathological features and tumor progression. The correlationship between SOX2 expression and ALBI grade as prognostic indicators were calculated. Survival rates were determined by Kaplan–Meier survival curves. SOX2 and Bcl-2 were remarkably overexpressed in HCC patients compared to controls (p = 0.04 and p = 0.003, respectively). A significant association was found for both SOX2 and Bcl-2 overexpression with TNM staging (p = 0.02, p = 0.04) and tumor grading (p = 0.01, p = 0.003), respectively. A significant correlation was observed: patients with SOX2 overexpression had a lower 5-year overall survival rate (p = 0.04); however, there was no significant association between Bcl-2 and survival (p = 0.5). Collectively, overexpression of SOX2 and Bcl-2, alone or combined, may be a potential marker to evaluate prognosis and response to HCC treatment.
DOI of the first publication: 10.3390/curroncol28040264
Link to this record: urn:nbn:de:bsz:291--ds-345809
ISSN: 1718-7729
Date of registration: 27-Aug-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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