Please use this identifier to cite or link to this item: doi:10.22028/D291-34579
Title: Abuse of nutmeg seeds: Detectable by means of liquid chromatography-mass spectrometry techniques?
Author(s): Manier, Sascha K.
Wagmann, Lea
Weber, Armin A.
Meyer, Markus R.
Language: English
Title: Drug Testing and Analysis
Volume: 13
Issue: 7
Pages: 1440-1444
Publisher/Platform: Wiley
Year of Publication: 2021
Free key words: GC-MS
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Numerous case reports of intoxications with nutmeg seeds (Myristica fragrans, Houtt.) can be found in literature often following their abuse, as psychotropic effects were described after ingestions of large doses. The successful detection of the main ingredients of the nutmeg seeds essential oil elemicin, myristicin, and safrole, as well as their metabolites in human urine by gas chromatography coupled to mass spectrometry (GC-MS) was already described. The aim of this study was to investigate the detectability of the main ingredients of nutmeg seeds and their metabolites in human blood and urine samples using liquid chromatography coupled to linear ion trap mass spectrometry (LC-LIT-MSn ) and liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS/MS) after nutmeg seed abuse. Sample material of three individuals was retrospectively investigated after a systematic screening approach indicated an intoxication with nutmeg seeds as a likely cause of symptoms. Metabolic patterns in plasma and urine using GC-MS were comparable with those described in earlier publications. Investigations using hyphenated liquid chromatography techniques lead to the detection of myristicin and safrole, as well as further metabolites not described using GC-MS and revealed sulfation as an additional Phase II metabolic pathway. These results might help to detect or confirm future intoxications with nutmeg seeds by using LC-MS techniques.
DOI of the first publication: 10.1002/dta.3027
Link to this record: urn:nbn:de:bsz:291--ds-345798
ISSN: 1942-7611
Date of registration: 26-Aug-2021
Description of the related object: Supporting Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Experimentelle und Klinische Pharmakologie und Toxikologie
Professorship: M - Prof. Dr. Markus Meyer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
dta.3027.pdf752,58 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons