Please use this identifier to cite or link to this item: doi:10.22028/D291-34578
Title: Current concepts of ectopic nodal inclusions with special emphasis on nodal nevi
Author(s): Müller, Cornelia Sigrid Lissi
Müller, Stephan G.
Vogt, Thomas
Pföhler, Claudia
Language: English
Title: Journal der Deutschen Dermatologischen Gesellschaft
Volume: 19
Issue: 8
Pages: 1145-1157
Publisher/Platform: Wiley
Year of Publication: 2021
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Nodal inclusions of ectopic tissue within lymph nodes are seen comparatively often in dermatopathology and general pathology. Glandular and nonglandular epithelium, as well as melanocytic nevi can be observed within lymph nodes and represent mostly incidental findings without any relevance. The main challenge in reporting these morphologic features is to differentiate such benign inclusions from metastatic settlements of distinct organ tumors. As sentinel node biopsy and lymph node dissection have become standard procedure in clinical oncology and have an immense clinical impact, the correct evaluation of these nodal inclusions is indispensable to avoid undertreatment or overtreatment of patients. In addition, the genesis of these inclusions has not yet been satisfactorily clarified. Two concepts have been laid out: the theory of benign metastases and the migration arrest theory. However, neither theory has so far been able to answer the following questions: Why do we find more nodal nevi in patients with melanoma who had a sentinel node biopsy than in patients without melanoma, and why do we not find nodal nevi in deep visceral lymph nodes? We present a comprehensive review of the current knowledge on nodal inclusions, proposing a concept for the pathogenesis of nodal nevi, to answer these questions.
DOI of the first publication: 10.1111/ddg.14521
Link to this record: urn:nbn:de:bsz:291--ds-345787
ISSN: 1610-0387
Date of registration: 26-Aug-2021
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
M - Dermatologie
Professorship: M - Prof. Dr. Thomas Vogt
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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