Please use this identifier to cite or link to this item: doi:10.22028/D291-34541
Title: Optimizing pressure-driven pulsatile flows in microfluidic devices
Author(s): Recktenwald, Steffen M.
Wagner, Christian
John, Thomas
Language: English
Title: Lab on a Chip
Volume: 21
Issue: 13
Pages: 2605–2613
Publisher/Platform: Royal Society of Chemistry
Year of Publication: 2021
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Unsteady and pulsatile flows receive increasing attention due to their potential to enhance various microscale processes. Further, they possess significant relevance for microfluidic studies under physiological flow conditions. However, generating a precise time-dependent flow field with commercial, pneumatically operated pressure controllers remains challenging and can lead to significant deviations from the desired waveform. In this study, we present a method to correct such deviations and thus optimize pulsatile flows in microfluidic experiments using two commercial pressure pumps. Therefore, we first analyze the linear response of the systems to a sinusoidal pressure input, which allows us to predict the time-dependent pressure output for arbitrary pulsatile input signals. Second, we explain how to derive an adapted input signal, which significantly reduces deviations between the desired and actual output pressure signals of various waveforms. We demonstrate that this adapted pressure input leads to an enhancement of the time-dependent flow of red blood cells in microchannels. The presented method does not rely on any hardware modifications and can be easily implemented in standard pressure-driven microfluidic setups to generate accurate pulsatile flows with arbitrary waveforms.
DOI of the first publication: 10.1039/d0lc01297a
Link to this record: urn:nbn:de:bsz:291--ds-345418
ISSN: 1473-0189
Date of registration: 17-Aug-2021
Description of the related object: Supplementary files
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Christian Wagner
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Files for this record:
File Description SizeFormat 
d0lc01297a.pdf3,28 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons