Please use this identifier to cite or link to this item: doi:10.22028/D291-34458
Title: Determinants of HIV-1 Late Presentation in Patients Followed in Europe
Author(s): Miranda, Mafalda N. S.
Pingarilho, Marta
Pimentel, Victor
Martins, Maria do Rosário O.
Vandamme, Anne-Mieke
Bobkova, Marina
Böhm, Michael
Seguin-Devaux, Carole
Paredes, Roger
Rubio, Rafael
Zazzi, Maurizio
Incardona, Francesca
Abecasis, Ana
Language: English
Title: Pathogens
Volume: 10
Issue: 7
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: HIV-1 infection
late presentation
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to identify determinants of late presentation in Europe based on the EuResist database with HIV-1 infected patients followed-up between 1981 and 2019. Our study includes clinical and socio-demographic information from 89,851 HIV-1 infected patients. Statistical analysis was performed using RStudio and SPSS and a Bayesian network was constructed with the WEKA software to analyze the association between all variables. Among 89851 HIV-1 infected patients included in the analysis, the median age was 33 (IQR: 27.0–41.0) years and 74.4% were males. Of those, 28,889 patients (50.4%) were late presenters. Older patients (>56), heterosexuals, patients originated from Africa and patients presenting with log VL >4.1 had a higher probability of being late presenters (p < 0.001). Bayesian networks indicated VL, mode of transmission, age and recentness of infection as variables that were directly associated with LP. This study highlights the major determinants associated with late presentation in Europe. This study helps to direct prevention measures for this population.
DOI of the first publication: 10.3390/pathogens10070835
Link to this record: urn:nbn:de:bsz:291--ds-344581
ISSN: 2076-0817
Date of registration: 3-Aug-2021
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Michael Böhm
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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