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Titel: Cylindrical Microparticles Composed of Mesoporous Silica Nanoparticles for the Targeted Delivery of a Small Molecule and a Macromolecular Drug to the Lungs: Exemplified with Curcumin and siRNA
VerfasserIn: Fischer, Thorben
Winter, Inga
Drumm, Robert
Schneider, Marc
Sprache: Englisch
Titel: Pharmaceutics
Bandnummer: 13
Heft: 6
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: nanotechnology
pulmonary delivery
TNFalpha inhibition
RNA release
inhalation therapy
aspheric drug delivery systems
curcumin delivery
synergistic effect
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.
DOI der Erstveröffentlichung: 10.3390/pharmaceutics13060844
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-342566
hdl:20.500.11880/31449
http://dx.doi.org/10.22028/D291-34256
ISSN: 1999-4923
Datum des Eintrags: 28-Jun-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/pharmaceutics13060844/s1
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Marc Schneider
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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