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Titel: Dental Biofilm and Saliva Microbiome and Its Interplay with Pediatric Allergies
VerfasserIn: Arweiler, Nicole B.
Rahmel, Vivien
Alhamwe, Bilal Alashkar
Alhamdan, Fahd
Zemlin, Michael
Boutin, Sébastien
Dalpke, Alexander
Renz, Harald
Sprache: Englisch
Titel: Microorganisms
Bandnummer: 9
Heft: 6
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: dental biofilm
saliva
oral microbiome
biofilm metabolism
16s-rRNA gene nextgeneration sequencing
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Little is known about the interplay and contribution of oral microorganisms to allergic diseases, especially in children. The aim of the clinical study was to associate saliva and dental biofilm microbiome with allergic disease, in particular with allergic asthma. In a single-center study, allergic/asthmatic children (n = 15; AA-Chd; age 10.7 ± 2.9), atopic/allergic children (n = 16; AT/AL-Chd; 11.3 ± 2.9), and healthy controls (n = 15; CON-Chd; age 9.9 ± 2.2) were recruited. After removing adhering biofilms from teeth and collecting saliva, microbiome was analyzed by using a 16s-rRNA gene-based next-generation sequencing in these two mediums. Microbiome structure differed significantly between saliva and dental biofilms (β-diversity). Within the groups, the dental biofilm microbiome of AA-Chd and AT/AL-Chd showed a similar microbial fingerprint characterized by only a small number of taxa that were enriched or depleted (4) compared to the CON-Chd, while both diseased groups showed a stronger microbial shift compared to CON-Chd, revealing 14 taxa in AA-Chd and 15 taxa in AT/AL-Chd that were different. This could be the first note to the contribution of dental biofilm and its metabolic activity to allergic health or disease.
DOI der Erstveröffentlichung: 10.3390/microorganisms9061330
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-342530
hdl:20.500.11880/31446
http://dx.doi.org/10.22028/D291-34253
ISSN: 2076-2607
Datum des Eintrags: 28-Jun-2021
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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