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Titel: Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases
VerfasserIn: Nasim, Muhammad Jawad
Zuraik, Mhd Mouayad
Abdin, Ahmad Yaman
Ney, Yannick
Jacob, Claus
Sprache: Englisch
Titel: Antioxidants
Bandnummer: 10
Heft: 6
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: aging
selenium
selenomethionine (SeMet)
reactive selenium species (RSeS)
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Selenium is an essential trace element. Although this chalcogen forms a wide variety of compounds, there are surprisingly few small-molecule organic selenium compounds (OSeCs) in biology. Besides its more prominent relative selenocysteine (SeCys), the amino acid selenomethionine (SeMet) is one example. SeMet is synthesized in plants and some fungi and, via nutrition, finds its way into mammalian cells. In contrast to its sulfur analog methionine (Met), SeMet is extraordinarily redox active under physiological conditions and via its catalytic selenide (RSeR’)/selenoxide (RSe(O)R’) couple provides protection against reactive oxygen species (ROS) and other possibly harmful oxidants. In contrast to SeCys, which is incorporated via an eloquent ribosomal mechanism, SeMet can enter such biomolecules by simply replacing proteinogenic Met. Interestingly, eukaryotes, such as yeast and mammals, also metabolize SeMet to a small family of reactive selenium species (RSeS). Together, SeMet, proteins containing SeMet and metabolites of SeMet form a powerful triad of redox-active metabolites with a plethora of biological implications. In any case, SeMet and its family of natural RSeS provide plenty of opportunities for studies in the fields of nutrition, aging, health and redox biology.
DOI der Erstveröffentlichung: 10.3390/antiox10060882
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-342504
hdl:20.500.11880/31441
http://dx.doi.org/10.22028/D291-34250
ISSN: 2076-3921
Datum des Eintrags: 28-Jun-2021
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Claus Jacob
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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