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doi:10.22028/D291-34263
Titel: | Timely and individualized heart failure management: need for implementation into the new guidelines |
VerfasserIn: | Abdin, Amr Bauersachs, Johann Frey, Norbert Kindermann, Ingrid Link, Andreas Marx, Nikolaus Lainscak, Mitja Slawik, Jonathan Werner, Christian Wintrich, Jan Böhm, Michael |
Sprache: | Englisch |
Titel: | Clinical Research in Cardiology |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Heart failure Outcomes Treatment Management |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Due to remarkable improvements in heart failure (HF) management over the last 30 years, a significant reduction in mortality and hospitalization rates in HF patients with reduced ejection fraction (HFrEF) has been observed. Currently, the optimization of guideline-directed chronic HF therapy remains the mainstay to further improve outcomes for patients with HFrEF to reduce mortality and HF hospitalization. This includes established device therapies, such as implantable defibrillators and cardiac resynchronization therapies, which improved patients' symptoms and prognosis. Over the last 10 years, new HF drugs have merged targeting various pathways, such as those that simultaneously suppress the renin–angiotensin–aldosterone system and the breakdown of endogenous natriuretic peptides (e.g., sacubitril/valsartan), and those that inhibit the If channel and, thus, reduce heart rate (e.g., ivabradine). Furthermore, the treatment of patient comorbidities (e.g., iron deficiency) has shown to improve functional capacity and to reduce hospitalization rates, when added to standard therapy. More recently, other potential treatment mechanisms have been explored, such as the sodium/glucose co-transporter inhibitors, the guanylate cyclase stimulators and the cardiac myosin activators. In this review, we summarize the novel developments in HFrEF pharmacological and device therapy and discuss their implementation strategies into practice to further improve outcomes. |
DOI der Erstveröffentlichung: | 10.1007/s00392-021-01867-2 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-342632 hdl:20.500.11880/31429 http://dx.doi.org/10.22028/D291-34263 |
ISSN: | 1861-0692 1861-0684 |
Datum des Eintrags: | 25-Jun-2021 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Innere Medizin |
Professur: | M - Prof. Dr. Michael Böhm |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Abdin2021_Article_TimelyAndIndividualizedHeartFa.pdf | 1,45 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons