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Titel: Timely and individualized heart failure management: need for implementation into the new guidelines
VerfasserIn: Abdin, Amr
Bauersachs, Johann
Frey, Norbert
Kindermann, Ingrid
Link, Andreas
Marx, Nikolaus
Lainscak, Mitja
Slawik, Jonathan
Werner, Christian
Wintrich, Jan
Böhm, Michael
Sprache: Englisch
Titel: Clinical Research in Cardiology
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2021
Freie Schlagwörter: Heart failure
Outcomes
Treatment
Management
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Due to remarkable improvements in heart failure (HF) management over the last 30 years, a significant reduction in mortality and hospitalization rates in HF patients with reduced ejection fraction (HFrEF) has been observed. Currently, the optimization of guideline-directed chronic HF therapy remains the mainstay to further improve outcomes for patients with HFrEF to reduce mortality and HF hospitalization. This includes established device therapies, such as implantable defibrillators and cardiac resynchronization therapies, which improved patients' symptoms and prognosis. Over the last 10 years, new HF drugs have merged targeting various pathways, such as those that simultaneously suppress the renin–angiotensin–aldosterone system and the breakdown of endogenous natriuretic peptides (e.g., sacubitril/valsartan), and those that inhibit the If channel and, thus, reduce heart rate (e.g., ivabradine). Furthermore, the treatment of patient comorbidities (e.g., iron deficiency) has shown to improve functional capacity and to reduce hospitalization rates, when added to standard therapy. More recently, other potential treatment mechanisms have been explored, such as the sodium/glucose co-transporter inhibitors, the guanylate cyclase stimulators and the cardiac myosin activators. In this review, we summarize the novel developments in HFrEF pharmacological and device therapy and discuss their implementation strategies into practice to further improve outcomes.
DOI der Erstveröffentlichung: 10.1007/s00392-021-01867-2
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-342632
hdl:20.500.11880/31429
http://dx.doi.org/10.22028/D291-34263
ISSN: 1861-0692
1861-0684
Datum des Eintrags: 25-Jun-2021
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Prof. Dr. Michael Böhm
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons