Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-34102
Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
vaccines-09-00493-v2.pdf1,43 MBAdobe PDFÖffnen/Anzeigen
Titel: Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations
VerfasserIn: Fortmann, Ingmar
Dammann, Marie-Theres
Humberg, Alexander
Siller, Bastian
Stichtenoth, Guido
Engels, Geraldine
Marißen, Janina
Faust, Kirstin
Hanke, Kathrin
Goedicke-Fritz, Sybelle UdsID
Derouet, Christoph
Meyer, Sascha
Stutz, Regine
Kaiser, Elisabeth UdsID
Herting, Egbert
Göpel, Wolfgang
Härtel, Christoph
Zemlin, Michael UdsID
on behalf of the German Neonatal Network (GNN) and the PRIMAL Consortium
Sprache: Englisch
In:
Titel: Vaccines
Bandnummer: 9
Heft: 5
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: immunization
prematurity
trained immunity
long-term outcome
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associated long-term consequences. We performed an observational study of the GNN between 1st January 2010 and 31st December 2019. The immunization status for the hexavalent and pneumococcal immunization was evaluated in n = 8401 preterm infants <29 weeks of gestation. Univariate analysis and logistic/linear regression models were used to identify risk factors for vaccination delay and outcomes at a 5-year follow-up. In our cohort n = 824 (9.8%) ELGANs did not receive a timely first immunization with the hexavalent and pneumococcal vaccine. Risk factors for delayed vaccination were SGA status (18.1% vs. 13.5%; OR 1.3; 95% CI: 1.1–1.7), impaired growth and surrogates for complicated clinical courses (i.e., need for inotropes, necrotizing enterocolitis). At 5 years of age, timely immunized children had a lower risk of bronchitis (episodes within last year: 27.3% vs. 37.7%; OR 0.60, 95% CI: 0.42–0.86) but spirometry measures were unaffected. In conclusion, a significant proportion of ELGANs are untimely immunized, specifically those with increased vulnerability, even though they might particularly benefit from the immune-promoting effects of a timely vaccination.
DOI der Erstveröffentlichung: 10.3390/vaccines9050493
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-341028
hdl:20.500.11880/31359
http://dx.doi.org/10.22028/D291-34102
ISSN: 2076-393X
Datum des Eintrags: 25-Mai-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/article/10.3390/vaccines9050493/s1
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons