Please use this identifier to cite or link to this item: doi:10.22028/D291-34078
Title: Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?
Author(s): Velot, Émilie
Madry, Henning
Venkatesan, Jagadeesh K.
Bianchi, Arnaud
Cucchiarini, Magali
Language: English
Title: Frontiers in Bioengineering and Biotechnology
Volume: 9
Publisher/Platform: Frontiers
Year of Publication: 2021
Free key words: extracellular vesicles
cell-to-cell communication
stem cells
regenerative medicine
cartilage regeneration
cell-free therapy
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: “Extracellular vesicles” (EVs) is a term gathering biological particles released from cells that act as messengers for cell-to-cell communication. Like cells, EVs have a membrane with a lipid bilayer, but unlike these latter, they have no nucleus and consequently cannot replicate. Several EV subtypes (e.g., exosomes, microvesicles) are described in the literature. However, the remaining lack of consensus on their specific markers prevents sometimes the full knowledge of their biogenesis pathway, causing the authors to focus on their biological effects and not their origins. EV signals depend on their cargo, which can be naturally sourced or altered (e.g., cell engineering). The ability for regeneration of adult articular cartilage is limited because this avascular tissue is partly made of chondrocytes with a poor proliferation rate and migration capacity. Mesenchymal stem cells (MSCs) had been extensively used in numerous in vitro and preclinical animal models for cartilage regeneration, and it has been demonstrated that their therapeutic effects are due to paracrine mechanisms involving EVs. Hence, using MSC-derived EVs as cell-free therapy tools has become a new therapeutic approach to improve regenerative medicine. EV-based therapy seems to show similar cartilage regenerative potential compared with stem cell transplantation without the associated hindrances (e.g., chromosomal aberrations, immunogenicity). The aim of this short review is to take stock of occurring EV-based treatments for cartilage regeneration according to their healing effects. The article focuses on cartilage regeneration through various sources used to isolate EVs (mature or stem cells among others) and beneficial effects depending on cargos produced from natural or tuned EVs.
DOI of the first publication: 10.3389/fbioe.2021.645039
Link to this record: urn:nbn:de:bsz:291--ds-340780
ISSN: 2296-4185
Date of registration: 19-May-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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