Please use this identifier to cite or link to this item: doi:10.22028/D291-34077
Title: The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics
Author(s): Tillmann, Sandra
Awwad, Hussain M.
MacPherson, Chad W.
Happ, Denise F.
Treccani, Giulia
Geisel, Jürgen
Tompkins, Thomas A.
Ueland, Per Magne
Wegener, Gregers
Obeid, Rima
Language: English
Title: Molecular Nutrition & Food research
Volume: 65
Issue: 9
Publisher/Platform: Wiley
Year of Publication: 2021
Free key words: choline
methyl‐deficient diet
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This study used Sprague Dawley rats to investigate whether a methyl‐deficient diet (MDD) may influence tryptophan/kynurenine pathways and cytokines and whether probiotics can mitigate these effects. Methods and Results Rats are fed a control or MDD diet. Animals on the MDD diet received vehicle, probiotics (L. helveticus R0052 and B. longum R0175), choline, or probiotics + choline for 10 weeks (n = 10 per group). Concentrations of plasma kynurenine metabolites and the methylation and inflammatory markers in plasma and liver are measured. Results MDD animals (vs controls) show upregulation of plasma kynurenine, kynurenic acid, xanthurenic acid, 3‐hydroxyxanthranilic acid, quinolinic acid, nicotinic acid, and nicotinamide (all p < 0.05). In the MDD rats, the probiotics (vs vehicle) cause lower anthranilic acid and a trend towards lower kynurenic acid and picolinic acid. Compared to probiotics alone, probiotics + choline is associated with a reduced enrichment of the bacterial strains in cecum. The interventions have no effect on inflammatory markers. Conclusions Probiotics counterbalance the effect of MDD diet and downregulate downstream metabolites of the kynurenine pathway.
DOI of the first publication: 10.1002/mnfr.202100078
Link to this record: urn:nbn:de:bsz:291--ds-340774
ISSN: 1613-4133
Date of registration: 19-May-2021
Description of the related object: Supporting Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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