Please use this identifier to cite or link to this item: doi:10.22028/D291-34056
Title: Differential Response of Pentanal and Hexanal Exhalation to Supplemental Oxygen and Mechanical Ventilation in Rats
Author(s): Müller-Wirtz, Lukas M.
Kiefer, Daniel
Knauf, Joschua
Floss, Maximilian A.
Doneit, Jonas
Wolf, Beate
Maurer, Felix
Sessler, Daniel I.
Volk, Thomas
Kreuer, Sascha
Fink, Tobias
Language: English
Title: Molecules
Volume: 26
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: mechanical ventilation
supplemental oxygen
oxygen toxicity
lipid peroxidation
volatile aldehydes
volatile organic compounds
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: High inspired oxygen during mechanical ventilation may influence the exhalation of the previously proposed breath biomarkers pentanal and hexanal, and additionally induce systemic inflammation. We therefore investigated the effect of various concentrations of inspired oxygen on pentanal and hexanal exhalation and serum interleukin concentrations in 30 Sprague Dawley rats mechanically ventilated with 30, 60, or 93% inspired oxygen for 12 h. Pentanal exhalation did not differ as a function of inspired oxygen but increased by an average of 0.4 (95%CI: 0.3; 0.5) ppb per hour, with concentrations doubling from 3.8 (IQR: 2.8; 5.1) ppb at baseline to 7.3 (IQR: 5.0; 10.8) ppb after 12 h. Hexanal exhalation was slightly higher at 93% of inspired oxygen with an average difference of 0.09 (95%CI: 0.002; 0.172) ppb compared to 30%. Serum IL-6 did not differ by inspired oxygen, whereas IL-10 at 60% and 93% of inspired oxygen was greater than with 30%. Both interleukins increased over 12 h of mechanical ventilation at all oxygen concentrations. Mechanical ventilation at high inspired oxygen promotes pulmonary lipid peroxidation and systemic inflammation. However, the response of pentanal and hexanal exhalation varies, with pentanal increasing by mechanical ventilation, whereas hexanal increases by high inspired oxygen concentrations.
DOI of the first publication: 10.3390/molecules26092752
Link to this record: urn:nbn:de:bsz:291--ds-340563
ISSN: 1420-3049
Date of registration: 17-May-2021
Description of the related object: Supplementary Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Anästhesiologie
Professorship: M - Prof. Dr. Thomas Volk
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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