Please use this identifier to cite or link to this item: doi:10.22028/D291-34055
Title: Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology
Author(s): Grässel, Susanne
Zaucke, Frank
Madry, Henning
Language: English
Title: Journal of Clinical Medicine
Volume: 10
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: OA
subchondral bone
topographical pattern
joint innervation
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Although osteoarthritis (OA) is the most common musculoskeletal condition that causes significant health and social problems worldwide, its exact etiology is still unclear. With an aging and increasingly obese population, OA is becoming even more prevalent than in previous decades. Up to 35% of the world’s population over 60 years of age suffers from symptomatic (painful, disabling) OA. The disease poses a tremendous economic burden on the health-care system and society for diagnosis, treatment, sick leave, rehabilitation, and early retirement. Most patients also experience sleep disturbances, reduced capability for exercising, lifting, and walking and are less capable of working, and maintaining an independent lifestyle. For patients, the major problem is disability, resulting from joint tissue destruction and pain. So far, there is no therapy available that effectively arrests structural deterioration of cartilage and bone or is able to successfully reverse any of the existing structural defects. Here, we elucidate novel concepts and hypotheses regarding disease progression and pathology, which are relevant for understanding underlying the molecular mechanisms as a prerequisite for future therapeutic approaches. Emphasis is placed on topographical modeling of the disease, the role of proteases and cytokines in OA, and the impact of the peripheral nervous system and its neuropeptides.
DOI of the first publication: 10.3390/jcm10091938
Link to this record: urn:nbn:de:bsz:291--ds-340550
ISSN: 2077-0383
Date of registration: 17-May-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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