Please use this identifier to cite or link to this item: doi:10.22028/D291-34053
Title: Connection between Periodontitis-Induced Low-Grade Endotoxemia and Systemic Diseases: Neutrophils as Protagonists and Targets
Author(s): Vitkov, Ljubomir
Muñoz, Luis E.
Knopf, Jasmin
Schauer, Christine
Oberthaler, Hannah
Minnich, Bernd
Hannig, Matthias
Herrmann, Martin
Language: English
Title: International Journal of Molecular Sciences
Volume: 22
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: blood transmission of PAMPs
trained immunity
loss of tolerance
neutrophil hyperresponsiveness
neutrophil-driven damages
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Periodontitis is considered a promoter of many systemic diseases, but the signaling pathways of this interconnection remain elusive. Recently, it became evident that certain microbial challenges promote a heightened response of myeloid cell populations to subsequent infections either with the same or other pathogens. This phenomenon involves changes in the cell epigenetic and transcription, and is referred to as “trained immunity”. It acts via modulation of hematopoietic stem and progenitor cells (HSPCs). A main modulation driver is the sustained, persistent low-level transmission of lipopolysaccharide from the periodontal pocket into the peripheral blood. Subsequently, the neutrophil phenotype changes and neutrophils become hyper-responsive and prone to boosted formation of neutrophil extracellular traps (NET). Cytotoxic neutrophil proteases and histones are responsible for ulcer formations on the pocket epithelium, which foster bacteremia and endoxemia. The latter promote systemic low-grade inflammation (SLGI), a precondition for many systemic diseases and some of them, e.g., atherosclerosis, diabetes etc., can be triggered by SLGI alone. Either reverting the polarized neutrophils back to the homeostatic state or attenuation of neutrophil hyper-responsiveness in periodontitis might be an approach to diminish or even to prevent systemic diseases.
DOI of the first publication: 10.3390/ijms22094647
Link to this record: urn:nbn:de:bsz:291--ds-340536
ISSN: 1422-0067
Date of registration: 17-May-2021
Faculty: M - Medizinische Fakultät
Department: M - Zahn-, Mund- und Kieferheilkunde
Professorship: M - Prof. Dr. Matthias Hannig
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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