Please use this identifier to cite or link to this item: doi:10.22028/D291-34052
Title: Nanotechnology in Bladder Cancer: Diagnosis and Treatment
Author(s): Barani, Mahmood
Hosseinikhah, Seyedeh Maryam
Rahdar, Abbas
Farhoudi, Leila
Arshad, Rabia
Cucchiarini, Magali
Pandey, Sadanand
Language: English
Title: Cancers
Volume: 13
Issue: 9
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: bladder cancer
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Bladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis and treatment of BC. For example, radiotherapy combined with chemotherapy and surgical, but residual tumor cells mostly cause tumor recurrence. In addition, chemotherapy after transurethral resection causes high side effects, and lack of selectivity, and low sensitivity in sensing. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. Nanotechnology has recently sparked an interest in a variety of areas, including medicine, chemistry, physics, and biology. Nanoparticles (NP) have been used in tumor therapies as appropriate tools for enhancing drug delivery efficacy and enabling therapeutic performance. It is noteworthy, nanomaterial could be reduced the limitation of conventional cancer diagnosis and treatments. Since, the major disadvantages of therapeutic drugs are their insolubility in an aqueous solvent, for instance, paclitaxel (PTX) is one of the important therapeutic agents utilized to treating BC, due to its ability to prevent cancer cell growth. However, its major problem is the poor solubility, which has confirmed to be a challenge when improving stable formulations for BC treatment. In order to reduce this challenge, anti-cancer drugs can be loaded into NPs that can improve water solubility. In our review, we state several nanosystem, which can effective and useful for the diagnosis, treatment of BC. We investigate the function of metal NPs, polymeric NPs, liposomes, and exosomes accompanied therapeutic agents for BC Therapy, and then focused on the potential of nanotechnology to improve conventional approaches in sensing.
DOI of the first publication: 10.3390/cancers13092214
Link to this record: urn:nbn:de:bsz:291--ds-340522
ISSN: 2072-6694
Date of registration: 17-May-2021
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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