Please use this identifier to cite or link to this item: doi:10.22028/D291-33972
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Title: Profiling of cytokines, chemokines and growth factors in saliva and gingival crevicular fluid
Author(s): Liu, Yong
Zhao, Renping
Reda, Bashar
Yang, Wenjuan
Hannig, Matthias
Qu, Bin
Language: English
Title: Cytokine : the official journal of the International Cytokine Society
Volume: 142
Publisher/Platform: Elsevier
Year of Publication: 2021
Publikation type: Journal Article
Abstract: In saliva and gingival crevicular fluid (GCF) soluble factors such as cytokines, chemokines and growth factors have shown a great potential serving as biomarkers for early detection and/or diagnosis of oral and systemic diseases. However, GCF and saliva, which one is a better source is still under debate. This study aimed to gain an overview of cytokines, chemokines and growth factors in saliva and GCF to pave the way for selecting suitable oral fluids for oral and systemic diseases. Multiplex cytokine assay was conducted to determine concentrations of cytokines, chemokines and growth factors in saliva and GCF samples from healthy subjects. The protocol for sample collection was carefully optimized. Stabilization, repeatability, and donor variation of the profiles were analyzed. We found that for different donors, cytokine and chemokine profiles showed unique patterns in saliva but similar patterns in GCF. In terms of growth factors, the profiles were individualized in saliva and GCF. All profiles stayed stable for the same healthy individual. In saliva, profiles of cytokines, chemokines and growth factors are individualized for different donors. In GCF, profiles of cytokines and chemokines are similar. Other factors, such as growth factors and T helper-related cytokines, are highly variable in donors. Profiles of soluble factors are not correlated in saliva and GCF. The comprehensive cytokine profiles in saliva and GCF reported in this work would serve as a good base for choosing promising cytokines for developing biomarkers in oral fluids.
DOI of the first publication: 10.1016/j.cyto.2021.155504
URL of the first publication:
Link to this record: hdl:20.500.11880/31267
ISSN: 1096-0023
Date of registration: 4-May-2021
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Biophysik
M - Zahn-, Mund- und Kieferheilkunde
Professorship: M - Prof. Dr. Matthias Hannig
M - Prof. Dr. Markus Hoth
Collections:Die Universitätsbibliographie

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