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doi:10.22028/D291-33868
Titel: | Can local treatment prolong the sensitivity of metastatic prostate cancer to androgen deprivation or even prevent castration resistance? |
VerfasserIn: | Niklas, Christina Saar, Matthias Nini, Alessandro Linxweiler, Johannes Siemer, Stefan Junker, Kerstin Stoeckle, Michael |
Sprache: | Englisch |
Titel: | World Journal of Urology |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | Metastatic prostate cancer Prostatectomy Androgen deprivation treatment Hormone-sensitivity Castration resistance |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Purpose A number of observational clinical studies suggest that prior primary tumor treatment favorably influences the course of metastatic prostate cancer (PCa), but its mechanisms of action are still speculative. Here, we describe the long-lasting sensitivity to various forms of androgen deprivation in patients after radical prostatectomy (RP) for locally advanced PCa as one potential mechanism. Methods A consecutive series of 115 radical prostatectomies after inductive therapy for T4 prostate cancer was re-analyzed, and long-term survival, as well as recurrence patterns and responses to different forms of hormonal manipulation, were assessed. Results The estimated biochemical response-free, PCa-specific, and overall survival rates after 200 months were 20%, 65%, and 47% with a median overall survival of 156 months. The majority of patients, although not cured of locally advanced PCa (84/115), showed long-term survival after RP. PCa-specific and overall survival rates of these 84 patients with biochemical recurrence were 61% and 44% at 150 months. Long-term sensitivity to ADT was found to be the main reason for the favorable tumor-specific survival in spite of biochemical recurrence. Conclusions Sensitivity to primary or secondary hormonal manipulation was the main reason for the long-term survival of patients who had not been cured by surgery only. The results suggest that treatment of the primary tumor-bearing prostate delays castration-resistant PCa and enhances the effect of hormonal therapies in a previously unknown manner. The underlying cellular and molecular mechanisms need to be explored in more detailed analyses, which could profoundly impact treatment concepts of locally advanced and metastatic PCa. |
DOI der Erstveröffentlichung: | 10.1007/s00345-020-03568-3 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-338682 hdl:20.500.11880/31177 http://dx.doi.org/10.22028/D291-33868 |
ISSN: | 1433-8726 0724-4983 |
Datum des Eintrags: | 19-Apr-2021 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary Information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-020-03568-3/MediaObjects/345_2020_3568_MOESM1_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-020-03568-3/MediaObjects/345_2020_3568_MOESM2_ESM.docx https://static-content.springer.com/esm/art%3A10.1007%2Fs00345-020-03568-3/MediaObjects/345_2020_3568_MOESM3_ESM.docx |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Niklas2021_Article_CanLocalTreatmentProlongTheSen.pdf | 592,71 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons