Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-33810
Titel: Time- and temperature-dependent postmortem concentration changes of the (synthetic) cannabinoids JWH-210, RCS-4, as well as ∆9-tetrahydrocannabinol following pulmonary administration to pigs
VerfasserIn: Schaefer, Nadine
Kröll, Ann-Katrin
Körbel, Christina
Laschke, Matthias W.
Menger, Michael D.
Maurer, Hans H.
Meyer, Markus R.
Schmidt, Peter H.
Sprache: Englisch
Titel: Archives of Toxicology
Bandnummer: 94
Heft: 5
Seiten: 1585–1599
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2020
Freie Schlagwörter: Synthetic cannabinoids
Tetrahydrocannabinol
Postmortem redistribution
Pigs
Pulmonary administration
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: In forensic toxicology, interpretation of postmortem (PM) drug concentrations might be complicated due to the lack of data concerning drug stability or PM redistribution (PMR). Regarding synthetic cannabinoids (SC), only sparse data are available, which derived from single case reports without any knowledge of dose and time of consumption. Thus, a controlled pig toxicokinetic study allowing for examination of PMR of SC was performed. Twelve pigs received a pulmonary dose of 200 µg/kg BW each of 4-ethylnaphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-210), 2-(4-methoxyphenyl)-1-(1-pentyl-indole-3-yl)methanone (RCS-4), and Δ9-tetrahydrocannabinol via an ultrasonic nebulizer. Eight hours after, the pigs were put to death with T61 and specimens of relevant tissues and body fluids were collected. Subsequently, the animals were stored at room temperature (n = 6) or 4 °C (n = 6) and further samples were collected after 24, 48, and 72 h each. Concentrations were determined following enzymatic cleavage and solid-phase extraction by liquid-chromatography tandem mass spectrometry applying the standard addition approach. High concentrations of the parent compounds were observed in lung, liver, kidney and bile fluid/duodenum content as well as brain. HO-RCS-4 was the most prevalent metabolite detected in PM specimens. In general, changes of PM concentrations were found in every tissue and body fluid depending on the PM interval as well as storage temperature.
DOI der Erstveröffentlichung: 10.1007/s00204-020-02707-4
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-338108
hdl:20.500.11880/31135
http://dx.doi.org/10.22028/D291-33810
ISSN: 1432-0738
0340-5761
Datum des Eintrags: 13-Apr-2021
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Chirurgie
M - Experimentelle und Klinische Pharmakologie und Toxikologie
M - Rechtsmedizin
Professur: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Markus Meyer
M - Prof. Dr. Peter Schmidt
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
Schaefer2020_Article_Time-AndTemperature-dependentP.pdf1,58 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons