Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-33806
Titel: Factors influencing the time to surgery after neoadjuvant chemotherapy in breast cancer patients
VerfasserIn: Müller, Carolin
Juhasz-Böss, Ingolf
Schmidt, Gilda
Jungmann, Peter
Solomayer, Erich-Franz
Breitbach, Georg-Peter
Juhasz-Böss, Stephanie
Sprache: Englisch
Titel: Archives of Gynecology and Obstetrics
Bandnummer: 301
Heft: 4
Seiten: 1055–1059
Verlag/Plattform: Springer Nature
Erscheinungsjahr: 2020
Freie Schlagwörter: Breast cancer
Neoadjuvant therapy
Time to surgery
Delaying factors
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Purpose It is suspected that delayed surgery after neoadjuvant chemotherapy (NACT) leads to a worse outcome in breast cancer patients. We therefore evaluated possible influencing factors of the time interval between the end of NACT and surgery. Methods All patients receiving NACT due to newly diagnosed breast cancer from 2015 to 2017 at the Department of Gynecology, Saarland University Medical Center, were included. The time interval between end of NACT and surgery was defined as primary endpoint. Possible delaying factors were investigated: age, study participation, outpatient and inpatient presentations, implants/expander, MRI preoperatively, discontinuation of chemotherapy, and genetic mutations. Results Data of 139 patients was analyzed. Median age was 53 years (22–78). The time interval between end of NACT and surgery was 28 days (9–57). Additional clinical presentations on outpatient basis added 2 days (p = 0.002) and on inpatient basis added 7 days to time to surgery (p < 0.001). Discontinuation of NACT due to chemotherapy side effects prolonged time to surgery by 8 days (p < 0.001), whereas discontinuation due to disease progress did not delay surgery (p = 0.6). In contrast, a proven genetic mutation shortened time to surgery by 7 days (p < 0.001). Patient’s age, participation in clinical studies, oncoplastic surgery, and preoperative MRI scans did not delay surgery. Conclusion Breast care centers should emphasize a reduction of clinical presentations and a good control of chemotherapy side effects for breast cancer patients to avoid delays of surgery after NACT.
DOI der Erstveröffentlichung: 10.1007/s00404-020-05494-6
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-338066
hdl:20.500.11880/31132
http://dx.doi.org/10.22028/D291-33806
ISSN: 1432-0711
0932-0067
Datum des Eintrags: 13-Apr-2021
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Frauenheilkunde
Professur: M - Prof. Dr. E.-F. Solomayer
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
Müller2020_Article_FactorsInfluencingTheTimeToSur.pdf558,33 kBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons