Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
doi:10.22028/D291-33778
Titel: | Expression of SEC62 Oncogene in Benign, Malignant and Borderline Melanocytic Tumors—Unmasking the Wolf in Sheep’s Clothing? |
VerfasserIn: | Müller, Cornelia S. L. Pföhler, Claudia Wahl, Maria Bochen, Florian Körner, Sandrina Kühn, Jan Philipp Bozzato, Alessandro Schick, Bernhard Linxweiler, Maximilian |
Sprache: | Englisch |
Titel: | Cancers |
Bandnummer: | 13 |
Heft: | 7 |
Verlag/Plattform: | MDPI |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | melanoma SEC62 carcinogenesis prognostic biomarker metastasis |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | SEC62 oncogene located at chromosomal region 3q26 encodes for a transmembrane protein of the endoplasmic reticulum (ER) and is expressed at high levels in numerous human malignancies. SEC62 overexpression has been associated with worse prognosis and high risk for lymphatic and distant metastases in head and neck cancer, cervical cancer, hepatocellular cancer, and lung cancer. However, its role in the development and tumor biology of melanocytic lesions has not been investigated so far. An immunohistochemical study including 209 patients with melanocytic lesions (malignant melanoma (MM), n = 93; melanoma metastases (MET), n = 28; Spitz nevi (SN), n = 29; blue nevi (BN), n = 21; congenital nevi (CN), n = 38) was conducted and SEC62 expression was correlated with clinical data including patient survival and histopathological characteristics. SN showed the highest SEC62 expression levels followed by MET, MM, CN, and BN. High SEC62 expression correlated with a shorter overall and progression-free survival in MM patients. Additionally, high Sec62 levels correlated significantly with higher tumor size (T stage), the presence of tumor ulceration, and the presence of lymph node as well as distant metastases. Strikingly, SEC62 expression showed a strong correlation with Clark level. Taken together, these data demonstrate that SEC62 is a promising prognostic marker in MM and has the potential to predict biological behavior and clinical aggressiveness of melanocytic lesions. |
DOI der Erstveröffentlichung: | 10.3390/cancers13071645 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-337782 hdl:20.500.11880/31113 http://dx.doi.org/10.22028/D291-33778 |
ISSN: | 2072-6694 |
Datum des Eintrags: | 12-Apr-2021 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Dermatologie M - Hals-Nasen-Ohrenheilkunde M - Medizinische Biochemie und Molekularbiologie |
Professur: | M - Prof. Dr. Bernhard Schick |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
cancers-13-01645.pdf | 1,04 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons