Please use this identifier to cite or link to this item: doi:10.22028/D291-33454
Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Hippo/Warts Signalling Effector Yorkie
Author(s): Steinmetz, Eva Louise
Dewald, Denise Nicole
Walldorf, Uwe
Language: English
Title: International Journal of Molecular Sciences
Volume: 22
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2021
Free key words: homeodomain-interacting protein kinase (Hipk)
serine/threonine kinase
Hippo/Warts signalling
Yorkie (Yki)
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Developmental growth and patterning are regulated by an interconnected signalling network of several pathways. In Drosophila, the Warts (Wts) kinase, a component of the Hippo signalling pathway, plays an essential role in regulating transcription and growth by phosphorylating its substrate Yorkie (Yki). The phosphorylation of Yki critically influences its localisation and activity as a transcriptional coactivator. In this study, we identified the homeodomain-interacting protein kinase (Hipk) as another kinase that phosphorylates Yki and mapped several sites of Yki phosphorylated by Hipk, using in vitro analysis: Ser168, Ser169/Ser172 and Ser255. These sites might provide auxiliary input for Yki regulation in vivo, as transgenic flies with mutations in these show prominent phenotypes; Hipk, therefore, represents an additional upstream regulator of Yki that works in concert with Wts.
DOI of the first publication: 10.3390/ijms22041862
Link to this record: urn:nbn:de:bsz:291--ds-334549
hdl:20.500.11880/30763
http://dx.doi.org/10.22028/D291-33454
ISSN: 1422-0067
Date of registration: 1-Mar-2021
Description of the related object: Supplementary Materials
Related object: https://www.mdpi.com/1422-0067/22/4/1862/s1
Faculty: M - Medizinische Fakultät
ZE - Zentrale Einrichtungen
Department: M - Anatomie und Zellbiologie
ZE - Zentrum für Human- und Molekularbiologie (ZHMB)
Professorship: M - Prof. Dr. Uwe Walldorf
ZE - Sonstige
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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