Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-33420
Titel: VEGFR2 and VEGFA polymorphisms are not associated with an inferior prognosis in Caucasian patients with aggressive B-cell lymphoma
VerfasserIn: Kaddu-Mulindwa, Dominic
Rosolowski, Maciej
Ziepert, Marita
Regitz, Evi
Assmann, Gunter
Bewarder, Moritz
Held, Gerhard
Pfreundschuh, Michael
Bittenbring, Jörg Thomas
Sprache: Englisch
Titel: European Journal of Haematology
Bandnummer: 106
Heft: 1
Seiten: 100-104
Verlag/Plattform: Wiley
Erscheinungsjahr: 2020
Freie Schlagwörter: diffuse large B‐cell lymphoma
polymorphism
single nucleotide polymorphisms
vascular endothelial growth factor
vascular endothelial growth factor receptor type 2
VEGF gene
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Purpose Previous published data showed an impact of single‐nucleotide polymorphisms in the VEGF A and VEGFR2 genes on the survival of patients with various malignancies, among others diffuse large B‐cell lymphoma (DLBCL). Patients and Methods We investigated the role of four VEGF‐A and two VEGFR‐2 gene polymorphisms on the outcome of 273 patients with diffuse large B‐cell lymphoma who were treated with R‐CHOP within a prospective, randomized trial of the German High‐Grade Non‐Hodgkin Lymphoma Study Group (DSHNHL). The genomic DNA samples were analyzed using commercial DNA Probes (Applied Biosystems, USA) to detect single‐nucleotide polymorphisms in the VEGF A rs699947, rs1570360, rs2010963, rs3025039 and rs1870377, and rs2305948 in the VEGFR2 receptor. Hundred healthy blood donors served as a control. Results There was no difference between the SNP allele frequencies in lymphoma patients compared to the control group for all investigated SNPs. None of the investigated SNPs was significantly associated with EFS or OS. After adjusting for the International Prognostic Index risk factors in a multivariate analysis, these results could be confirmed. Conclusion Single‐nucleotide polymorphisms of the VEGF and VEGFR2 were not associated with a worse outcome in Caucasian patients with DLBCL.
DOI der Erstveröffentlichung: 10.1111/ejh.13526
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-334208
hdl:20.500.11880/30733
http://dx.doi.org/10.22028/D291-33420
ISSN: 1600-0609
0902-4441
Datum des Eintrags: 25-Feb-2021
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.13526&file=ejh13526-sup-0001-FigureS1.pdf
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.13526&file=ejh13526-sup-0002-FigureS2.pdf
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.13526&file=ejh13526-sup-0003-TableS1.docx
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Fejh.13526&file=ejh13526-sup-0004-TableS2.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
ejh.13526.pdf253,09 kBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons